Thirty-two-year trends in anticholinergic burden and associated mortality among US older adults: a population-based study.
Background Anticholinergic burden (AB) is linked to adverse health outcomes and mortality among older adults. Yet, the national trends in AB and its long-term mortality risk are not well-defined. Methods We analysed data from 16 188 older adults in the National Health and Nutrition Examination Surve...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513177&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513177 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513177 10.1093/ageing/afag049 ppf: 1 ppct: 10 formats: tig: atl: Thirty-two-year trends in anticholinergic burden and associated mortality among US older adults: a population-based study. aug: au: Wei, Kai Sun, Shuimei Chen, Chun Yang, Yanping Li, Dongmei Liu, Yan Tang, Cailin Jiang, Wenbin Bai, Xue Hu, Kui affil: Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China Department of Pharmacy, Guizhou Branch of Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Guiyang, Guizhou, China Department of Clinical Laboratory, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, Guizhou, ChinaDepartment of Pharmacy, Guizhou Branch of Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Guiyang, Guizhou, China Department of Cardiovascular Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China su: United States Drug side effects Causes of death Old age Cardiovascular disease related mortality Mortality risk factors Parasympathomimetic agents Risk assessment Research funding Logistic regression analysis Descriptive statistics Disease prevalence Confidence intervals Tumors Data analysis software Proportional hazards models sug: subj: Drug side effects Causes of death Old age United States Cardiovascular disease related mortality Mortality risk factors Parasympathomimetic agents Risk assessment Research funding Logistic regression analysis Descriptive statistics Disease prevalence Confidence intervals Tumors Data analysis software Proportional hazards models keyword: anticholinergic agents anticholinergic burden copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag049 inLanguage:en mortality national health and nutrition examination survey older adult older adults prevalence publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41785066/ weight measurement scales anticholinergic agents anticholinergic burden copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag049 inLanguage:en mortality national health and nutrition examination survey older adult older adults prevalence publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41785066/ weight measurement scales ab: Background Anticholinergic burden (AB) is linked to adverse health outcomes and mortality among older adults. Yet, the national trends in AB and its long-term mortality risk are not well-defined. Methods We analysed data from 16 188 older adults in the National Health and Nutrition Examination Survey (NHANES) spanning 32 years. AB was assessed using the 2023 American Geriatrics Society Beers Criteria® and four validated scales (ARS, ADS, ACB and ACSBC). Age-standardised prevalence trends were examined using survey-weighted logistic regression. Mortality outcomes were ascertained through linkage to the National Death Index and analysed with Cox proportional hazards models to estimate adjusted hazard ratios (HRs). Results From 1988–94 to 2017–March 2020, the prevalence of any strong anticholinergic medication use and high AB (score ≥ 3) declined significantly across all scales (all P < .05). During a median follow-up of 81 months, 9006 deaths (49.3%) occurred. After comprehensive adjustment for covariates, high AB was independently associated with elevated all-cause mortality (ADS: HRs 1.65, 95% CI 1.51–1.81; ACB: HRs 1.54, 95% CI 1.41–1.68), cardiovascular mortality (ADS: HRs 1.94, 95% CI 1.71–2.20; ACB: HRs 1.66, 95% CI 1.46–1.88) and cancer mortality (ADS: HRs 1.40, 95% CI 1.18–1.68; ACB: HRs 1.31, 95% CI 1.09–1.57). Conclusions While the prevalence of AB among US older adults has declined over the past three decades, high exposure remains a strong, independent predictor of all-cause, cardiovascular and cancer mortality. These findings highlight the ongoing need for safer prescribing and sustained deprescribing initiatives in geriatric care. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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