Investigating the relationship between gut microbiota and electrocortical signatures of feedback processing: an ERP study.
Rationale: Evaluative processing of action outcome is considered crucial for learning and adaptive adjustments of behaviour. Feedback-related negativity (FRN) is an event-related potential elicited by feedback presentation, with implicated neural sources in the anterior cingulate cortex. Bidirection...
| Publicado en: | Psychopharmacology Vol. 243; no. 4; pp. 767 - 779 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192617468&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192617468 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Apr2026 vid: 243 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 192617468 187592023 10.1007/s00213-025-06878-9 192617468 ppf: 767 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigating the relationship between gut microbiota and electrocortical signatures of feedback processing: an ERP study. aug: au: Lenzoni, Sabrina Hunter, Kirsty Heym, Nadja Heasman, Bryony Blanco, Stephanie Walton, Gemma Gibson, Glenn Poveda, Carlos Baguley, Thomas Wang, Grace Y. Mograbi, Daniel C. Sumich, Alexander affil: https://ror.org/01dg47b60 Department of Psychology, Pontifical University of Rio de Janeiro, 22451-900, Rio de Janeiro, Brazil sug: ab: Rationale: Evaluative processing of action outcome is considered crucial for learning and adaptive adjustments of behaviour. Feedback-related negativity (FRN) is an event-related potential elicited by feedback presentation, with implicated neural sources in the anterior cingulate cortex. Bidirectional communications within the brain-gut-microbiota axis modulate cognition and behaviour, and microbial composition has been associated with medial prefrontal cortex function and clinical risk for depression. Objectives: The present study aimed to investigate associations between specific gut microbiota and the FRN. Methods: Twenty-nine healthy participants completed self-report measures of depression and a Faces and Feedback task during electroencephalography recording. Select implicated microbiota genera were enumerated from stool samples (Clostridium, Lactobacillus), along with plasma C-reactive protein (CRP) as an index of systemic inflammation. Results: FRN amplitude for positive feedback was positively correlated with microbiota abundance. The relationship between Clostridium and FRN was confirmed by multilevel modelling analysis, controlling for depression and CRP. The latter was positively associated with FRN amplitude. Conclusions: Findings suggest that the brain-gut-microbiota-axis may modulate or be modulated by self-monitoring processes. The current work provides insights into neurophysiological mechanisms underlying reward processing and indicates novel directions for therapeutic interventions, such as those that modulate the gut microbiome. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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