Benzaldehyde and azaphilone derivatives from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89.
Two new compounds including one benzaldehyde (1) and one azaphilone (2) were isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89 together with nine known compounds (3–11). Their structures were determined by spectroscopic evidences. The absolute configuration of 2 was establis...
| Publicado en: | Natural Product Research Vol. 40; no. 7; pp. 1905 - 1913 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192628838&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192628838 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Apr2026 vid: 40 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 192628838 181876204 10.1080/14786419.2024.2442101 192628838 ppf: 1905 ppct: 8 formats: tig: atl: Benzaldehyde and azaphilone derivatives from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89. aug: au: Saetang, Praphatsorn Rukachaisirikul, Vatcharin Saithong, Saowanit Phongpaichit, Souwalak Preedanon, Sita Sakayaroj, Jariya affil: Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand sug: ab: Two new compounds including one benzaldehyde (1) and one azaphilone (2) were isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89 together with nine known compounds (3–11). Their structures were determined by spectroscopic evidences. The absolute configuration of 2 was established by comparison of the ECD data with those of the previously reported data of compound 7 as well as the biosynthetic consideration. Compound 1 displayed potent cytotoxic activity against MCF-7 cells with an IC50 value of 9 µM, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds 3 and 8 were moderately active against Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus, respectively, with equal MIC values of 64 µg/mL. In addition, they were non-cytotoxic to noncancerous Vero cells. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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