Novel 1,2,4‐Triazole–Thiopyrimidine Hybrids as COX‐2 Inhibitors: Synthesis, ADME Profiling, Antioxidant Activity, and Molecular Docking.

This work reports the design, synthesis, and multilevel evaluation of 20 new S‐alkyl derivatives of 6‐(5‐mercapto‐4‐ethyl‐4H‐1,2,4‐triazol‐3‐yl)pyrimidine‐2,4(1H,3H)‐dione as potential selective cyclooxygenase‐2 (COX‐2) inhibitors with antioxidant properties. The aim was to establish structure–prope...

Descripción completa

Detalles Bibliográficos

Publicado en:	BioMed Research International Vol. 2026; pp. 1 - 23
Autores principales:	Karpenko, Yuriy, Parchenko, Volodymyr, Panasenko, Olexandr, Bihdan, Oleksii, Pukhalska, Iryna, Nikiforov, Oleg, Nahorna, Nataliia, Nahornyi, Volodymyr, Roik, Olena, Gurumallesh Prabu, Poorani
Formato:	pictorial research tables/charts Journal Article
Publicado:	Wiley-Blackwell 3/31/2026
Acceso en línea:	Ver este registro en EBSCOhost