Defining Multiple Fibroadenomas: A Systematic Review of Clinical Characteristics and Management.
This review systematically evaluates the published literature on multiple fibroadenomas (MFAs) of the breast, focusing on clinical presentation, diagnostic challenges, and treatment strategies. A systematic search of PubMed, Medline, Scopus, and Embase from 1948 to June 2025 was conducted using a Bo...
| Publicado en: | Breast Journal Vol. 2026; pp. 1 - 12 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/1/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192690644&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192690644 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: 4/1/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 192690644 192690644 192690644 10.1155/tbj/5572826 192690644 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Defining Multiple Fibroadenomas: A Systematic Review of Clinical Characteristics and Management. aug: au: Math, Prathiksha Sajith, Gayathri Mahadevappa, Kiran Hegde, Shalini G. Wani, Imtiaz affil: Department of Paediatric Surgery,, St. John's Medical College Hospital,, Bangalore, Karnataka, India sug: subj: Neoplasms, Fibrous Tissue Diagnosis Breast Neoplasms Diagnosis Neoplasms, Fibrous Tissue Therapy Breast Neoplasms Therapy Nomenclature Human Female Systematic Review PubMed Medline Embase Neoplasms, Fibrous Tissue Pathology Neoplasms, Fibrous Tissue Ultrasonography Neoplasms, Fibrous Tissue Radiography Neoplasms, Fibrous Tissue Risk Factors Breast Neoplasms Pathology Breast Neoplasms Ultrasonography Breast Neoplasms Radiography Breast Neoplasms Risk Factors Disease Attributes Ultrasonography Methods Magnetic Resonance Imaging Methods Biopsy, Needle Methods Contraceptives, Oral Adverse Effects Cyclosporine Adverse Effects Risk Assessment Descriptive Statistics Female ab: This review systematically evaluates the published literature on multiple fibroadenomas (MFAs) of the breast, focusing on clinical presentation, diagnostic challenges, and treatment strategies. A systematic search of PubMed, Medline, Scopus, and Embase from 1948 to June 2025 was conducted using a Boolean search strategy following the PRISMA 2020 guidelines. Of the 409 studies initially screened, 43 met the inclusion criteria. The level of evidence was assessed using the Oxford Centre for Evidence‐Based Medicine guidelines, and 72% were found to be of Levels 4 and 5. MFA most commonly affects adolescents. Bilateral involvement was observed in 64.6% of patients, and more than 10 lesions were present in 52% of cases. Risk factors included hormonal contraceptive use, family history, and cyclosporine therapy. Ultrasonography was the most common diagnostic tool, followed by MRI and FNAC. Treatment was mainly surgical, with recurrence noted in 15.4% of patients. There was no evidence to suggest that the risk of cancer in MFA was greater than that of solitary FA. The review highlights inconsistencies in MFA definitions and calls for consensus on diagnostic criteria, prospective research, and the creation of standardized treatment algorithms to improve care and outcomes for this particularly distressing subset of benign breast diseases. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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