The effects of neuromuscular training on functional outcome measures in patients with knee osteoarthritis: a systematic review and meta-analysis.
Background: Previous studies indicate exercises are a crucial component in managing knee osteoarthritis (KOA). It appears interventions targeting sensorimotor performance may offer advantages for individuals with KOA. This study aimed to perform a systematic review and meta-analysis to evaluate the...
| Published in: | Physiotherapy Theory & Practice Vol. 42; no. 4; pp. 595 - 609 |
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| Main Authors: | , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
Apr2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192729125&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192729125 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09593985 BCJ jtl: Physiotherapy Theory & Practice issn: 09593985 maglogo: Y pubinfo: dt: Apr2026 vid: 42 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 192729125 189101284 192729125 192729125 10.1080/09593985.2025.2584359 192729125 ppf: 595 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effects of neuromuscular training on functional outcome measures in patients with knee osteoarthritis: a systematic review and meta-analysis. aug: au: Emami, Fatemeh Sadeghi, Masoumeh Ebrahimzadeh, Mohammad Hosein Pirayeh, Nahid Ebrahimzadeh, Saeedeh Mostafaee, Neda affil: Department of Physiotherapy, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran sug: subj: Neuromuscular Facilitation Functional Assessment Osteoarthritis, Knee Rehabilitation Training Effect (Physiology) Patient-Reported Outcomes Human Systematic Review Meta Analysis Physiotherapy Evidence Database PubMed Medline Confidence Intervals Scales Quality of Life Balance, Postural Muscle Strength Funding Source Quadriceps Muscles Hamstring Muscles Checklists Descriptive Statistics Data Analysis Software ab: Background: Previous studies indicate exercises are a crucial component in managing knee osteoarthritis (KOA). It appears interventions targeting sensorimotor performance may offer advantages for individuals with KOA. This study aimed to perform a systematic review and meta-analysis to evaluate the impact of neuromuscular exercises (NEMEX) on patient-reported and performance-based outcome measures of physical function in this population. Methods: We systematically searched for studies in electronic databases (Web of Science, Science Direct, Physiotherapy Evidence Database (PEDro), PubMed, Scopus, Medline and ProQuest) from 1990 to March 2025, prioritizing KOOS and WOMAC as primary outcomes and other measures as secondary outcomes. In meta-analyses, we used weighted mean differences along with 95% confidence interval to assess absolute difference in KOOS, WOMAC, timed up-and-go and chair stand test scores. We used forest plots to represent our data. Results: Eight articles of clinical trials were eligible to include in this review. The meta-analysis showed KOOS-quality-of-life scores (mean difference = 5.36, 95%CI = 1.07 to 9.65, p =.01, I2 = 0.00%) were significantly higher in the NEMEX group compared to control groups. The WOMAC (mean difference = −5.21, 95%CI = −10.31 to −0.11, p =.05, I2 = 81.48%) showed lower scores trending toward significance in NEMEX group compared to control groups. The timed up-and-go test (mean difference = -0.05, 95%CI = −0.52 to 0.42, p =.58, I2 = 0.00%) and chair stand test (mean difference = 0.47, 95%CI = -0.31 to 1.24, p =.08, I2 = 67.87%) indicated no significant difference between the NEMEX and control groups. However, studies assessing the effect of NEMEX on stair climb test, Y balance test, muscle strength of quadriceps and hamstrings, and quality of life questionnaire had conflicting results. Conclusion: The NEMEX effectively promoted quality of life among individuals with KOA and should be included in rehabilitation programs. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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