Individual characteristics and time‐updated factors associated with antiretroviral treatment interruptions among people living with HIV in British Columbia, Canada.
Background: Treatment interruptions (TIs) may lead to adverse health outcomes for people living with HIV. This study explores individual characteristics as well as proximal factors associated with TIs among people living with HIV in British Columbia (BC), Canada. Methods: Between January 2016 and Se...
| Publicado en: | HIV Medicine Vol. 27; no. 4; pp. 585 - 597 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192786142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192786142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14642662 F0I jtl: HIV Medicine issn: 14642662 maglogo: Y pubinfo: dt: Apr2026 vid: 27 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 192786142 190687095 192786142 192786142 10.1111/hiv.70188 192786142 ppf: 585 ppct: 12 formats: tig: atl: Individual characteristics and time‐updated factors associated with antiretroviral treatment interruptions among people living with HIV in British Columbia, Canada. aug: au: Foncham, Jermia Azarmju, Farnaz Shen, Tian Salters, Kate Trigg, Jason Barrios, Rolando Hogg, Robert S. Moher, Matthew Selfridge, Marion Kling, Rakel Arora, Kartik Wesseling, Tim Changir, Antonio Marante Montaner, Julio S. G. Moore, David M. affil: British Columbia Centre for Excellence in HIV/AIDS, Vancouver British Columbia,, Canada sug: subj: HIV Infections Drug Therapy Anti-HIV Agents Therapeutic Use Structured Treatment Interruption Risk Assessment Human Funding Source British Columbia Male Female Adult Middle Age Aged Aged, 80 and Over Prospective Studies Descriptive Statistics Purposive Sample Chi Square Test Fisher's Exact Test Wilcoxon Rank Sum Test Odds Ratio Cox Proportional Hazards Model Data Analysis Software Questionnaires Scales HIV-Positive Persons Anti-Retroviral Agents Therapeutic Use Homelessness Incarceration Violence Age Factors Marital Status Persons Who Use Intravenous Drugs Men Who Have Sex With Men Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Treatment interruptions (TIs) may lead to adverse health outcomes for people living with HIV. This study explores individual characteristics as well as proximal factors associated with TIs among people living with HIV in British Columbia (BC), Canada. Methods: Between January 2016 and September 2018, eligible people living with HIV aged ≥19 years across BC completed three surveys, 18 months apart, assessing demographics, health behaviours and healthcare engagement. TIs (≥60 days late for ART refills) were identified through the BC HIV Drug Treatment Program database from enrolment until December 2020. We used Cox proportional hazards models to analyse baseline factors associated with time‐to‐first TI and generalized linear mixed models to examine time‐updated factors related to TIs within 3 months of a study visit. Results: Among 639 participants receiving antiretroviral therapy (ART) at enrolment, 21.3% were women, 59% were men who have sex with men and 24.1% had ≥1 TI over the study period. Factors associated with time‐to‐first TI included history of incarceration (adjusted hazard ratio [AHR] = 1.97; p < 0.001), experiencing violence (AHR = 1.94; p = 0.019) and age ≥ 60 years (AHR = 0.39; p = 0.007); 50–59 years (AHR = 0.63; p = 0.038) and 40–49 years (AHR = 0.61; p = 0.036) versus <40 years. TIs within 3 months of a study visit were associated with being single (adjusted odds ratio [AOR] = 3.63; p = 0.005), recent homelessness (AOR = 2.29; p = 0.049) and recent injection drug use (AOR = 3.55; p <0.001) measured at the time of the visit. Conclusion: Analysing TIs using a time‐to‐event approach identified non‐modifiable risk markers (history of incarceration, experiencing violence and age), whereas our time‐updated analysis found modifiable factors (being single, recent homelessness and recent injection drug use). The latter should be examined further as potential targets for therapeutic interventions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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