Shifts in the Lung Microbiota and Antibiotic Resistance Genes Occur With Aging in Patients With Lower Respiratory Tract Infections.
Lower respiratory tract infections (LRTIs) are a leading cause of critical illness and mortality. The lung microbiome represents an important reservoir for the exchange of antibiotic resistance genes (ARGs). The pathogenic microbes remain poorly understood among different age groups, including child...
| Publicado en: | BioMed Research International Vol. 2026; pp. 1 - 17 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/6/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192786156&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192786156 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/6/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 192786156 192786156 192786156 10.1155/bmri/9038281 192786156 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Shifts in the Lung Microbiota and Antibiotic Resistance Genes Occur With Aging in Patients With Lower Respiratory Tract Infections. aug: au: Chen, Xiaoming Dong, Tingyan Wu, Dongliang Pan, Quanguan Wei, Jinhua Liang, Guangwen Lin, Zetai Gurumallesh Prabu, Poorani affil: Department of Pediatrics,, Huangpu People′s Hospital of Zhongshan,, Zhongshan, Guangdong,, China sug: subj: Lung Microbiology Microbiota Drug Resistance, Microbial Genes Aging Respiratory Tract Infections Human Infant, Newborn Infant Child, Preschool Child Adolescence Young Adult Adult Middle Age Aged Aged, 80 and Over Retrospective Design Bronchoalveolar Lavage Age Factors Candida Albicans Sequence Analysis Molecular Diagnostic Techniques Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Lower respiratory tract infections (LRTIs) are a leading cause of critical illness and mortality. The lung microbiome represents an important reservoir for the exchange of antibiotic resistance genes (ARGs). The pathogenic microbes remain poorly understood among different age groups, including children (0–17 years), youth (18–39 years), middle‐aged adults (40–64 years), and older adults (65–99 years). We conducted a retrospective study of 699 bronchoalveolar lavage fluid (BALF) samples from LRTI patients aged 30 days to 99 years. The differences in the lung microbiome and ARG expression shift with age were evaluated based on targeted next‐generation sequencing (tNGS) results. Correlation analysis revealed that age had a strongly positive correlation effect on the relative abundances of Candida albicans, Candida glabrata, Corynebacterium striatum, and Stenotrophomonas maltophilia. Meanwhile, age had a largely negative correlation effect on Enterococcus faecium and Mycoplasma pneumoniae. We found that ARG expression was significantly higher in adults compared with children. The beta‐lactam ARG TEM was the most abundant, and the primary carrier of ARGs was Streptococcus in the LRTI microbiota. The proportion of adults expressing beta‐lactams, aminoglycosides, and phenicol antibiotic types was higher compared to children. Our results indicated that ARGs in the human LRTI microbiota accumulate and become more complex with age, as older groups tend to harbor the highest abundance of these genes. Collectively, these results presented the respiratory tract core microbiota and ARGs in different age groups, supplying a foundation for microbiome‐targeted interventions and emphasizing the potential of tNGS to improve clinical diagnosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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