Adverse childhood experiences and sarcopenia: a prospective study embedded in the Canadian Longitudinal Study on Aging.
Background Adverse childhood experiences (ACEs), known to increase lifelong health risks, have recently been linked to frailty. This study examined whether ACEs predict the onset and progression of sarcopenia, a core component of the frailty phenotype. Methods We analysed 23 476 participants aged 45...
| Publicado en: | Age & Ageing Vol. 55; no. 3; pp. 1 - 10 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Mar2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192797120&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192797120 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2026 vid: 55 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192797120 10.1093/ageing/afag050 ppf: 1 ppct: 9 formats: tig: atl: Adverse childhood experiences and sarcopenia: a prospective study embedded in the Canadian Longitudinal Study on Aging. aug: au: Dimitriadis, Menelaos M Kokkeler, Kitty J Hoogendijk, Emiel O Marijnissen, Radboud M Aprahamian, Ivan Jeuring, Hans W Voshaar, R C Oude affil: University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands Department of Old Age Psychiatry, Pro Persona Groep, Wolfheze, GE, The Netherlands Amsterdam UMC Locatie VUmc—Department of Epidemiology & Data Science, Amsterdam Public Health Research Institute, P.O. Box 7057, Amsterdam 1081 HV, The Netherlands Faculdade de Medicina de Jundiaí—Internal Medicine, Jundiaí, SP, Brazil su: Canada Income Socioeconomic factors Retrospective studies Adverse childhood experiences Educational attainment Mental depression Risk assessment Age of onset Leanness Data analysis Center for Epidemiologic Studies Depression Scale Skeletal muscle Research funding Frail elderly Multiple regression analysis Logistic regression analysis Descriptive statistics Multivariate analysis Longitudinal method Odds ratio Statistics Confidence intervals Walking speed Data analysis software Sarcopenia Disease progression Grip strength Regression analysis sug: subj: Income Socioeconomic factors Retrospective studies Adverse childhood experiences Educational attainment Mental depression Canada Risk assessment Age of onset Leanness Data analysis Center for Epidemiologic Studies Depression Scale Skeletal muscle Research funding Frail elderly Multiple regression analysis Logistic regression analysis Descriptive statistics Multivariate analysis Longitudinal method Odds ratio Statistics Confidence intervals Walking speed Data analysis software Sarcopenia Disease progression Grip strength Regression analysis keyword: adverse childhood experiences aged aging copyrightHolder:British Geriatrics Society copyrightYear:2026 depression depressive disorders ethnic group follow-up https://dx.doi.org/10.1093/ageing/afag050 inLanguage:en muscle mass older adult older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41839176/ sarcopenia adverse childhood experiences aged aging copyrightHolder:British Geriatrics Society copyrightYear:2026 depression depressive disorders ethnic group follow-up https://dx.doi.org/10.1093/ageing/afag050 inLanguage:en muscle mass older adult older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41839176/ sarcopenia ab: Background Adverse childhood experiences (ACEs), known to increase lifelong health risks, have recently been linked to frailty. This study examined whether ACEs predict the onset and progression of sarcopenia, a core component of the frailty phenotype. Methods We analysed 23 476 participants aged 45–85 years in the Canadian Longitudinal Study on Aging with 3-year follow-up (49.5% female; mean age 62.1 ± 9.9). Eight ACEs were assessed using validated retrospective instruments. Associations between ACE count and incident sarcopenia (revised European Working groups on Sarcopenia in Older People criteria) were evaluated using multivariable logistic regression, while changes in continuous sarcopenia components were assessed with lagged linear models adjusted for age, sex and ethnicity. Moderating effects of age, sex, ethnicity, depression (CESD ≥ 10) and socioeconomic position (education, income) were explored. Results Overall, 12.7% of participants reported a high ACE burden (≥3). Among 21 910 participants without baseline sarcopenia, 614 (2.8%) developed sarcopenia. Depression, but not sociodemographic factors, moderated the ACE–sarcopenia association. ACE count predicted incident sarcopenia among depressed participants [OR (odds ratio) = 1.10 (95% (confidence interval) CI: 1.02–1.20), P = .016], but not among nondepressed participants [OR = 0.98 (95% CI: 0.93–1.03), P = .399]. Depression also moderated ACE-related declines in lean muscle mass and handgrip strength. Post hoc analyses showed that ACE-related worsening of chair rise performance and gait speed was mediated by depression. Conclusions ACEs are associated with modest declines in muscle mass and function, with depression emerging as a key pathway linking early adversity to later-life sarcopenia. These findings highlight the need to integrate psychosocial history and mental health into risk stratification and preventive strategies for functional decline. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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