The association between midlife neighbourhood walkability and Alzheimer's disease in women: a prospective nested case–control study.
Background The role of modifiable environmental factors in Alzheimer's disease (AD) risk remains poorly understood. Built environment features such as neighbourhood walkability (NW) may influence long-term cognitive health among women. Methods The New York University Women's Health Study recruited 1...
| Publicado en: | Age & Ageing Vol. 55; no. 3; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Mar2026
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192797123&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192797123 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2026 vid: 55 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192797123 10.1093/ageing/afag054 ppf: 1 ppct: 9 formats: tig: atl: The association between midlife neighbourhood walkability and Alzheimer's disease in women: a prospective nested case–control study. aug: au: Walker, Emma Wu, Fen Rundle, Andrew G Hua, Simin Quinn, James W Neckerman, Kathryn M Afanasyeva, Yelena Arslan, Alan A Koenig, Karen L Zeleniuch-Jacquotte, Anne affil: NYU Grossman Long Island School of Medicine, Mineola, NY, USA Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA Columbia Population Research Center, Columbia University, New York, NY, USA su: New York (State) Psychology of women Case-control method Medical screening Anthropometry Social support Women's health Built environment Cognition Mid-life crisis Active aging Alzheimer's disease risk factors Risk assessment Research funding Body mass index Logistic regression analysis Descriptive statistics Walking Longitudinal method Odds ratio Mammograms Data analysis software Confidence intervals Neighborhood characteristics Sensitivity & specificity (Statistics) sug: subj: Psychology of women Case-control method Medical screening Anthropometry Social support Women's health Built environment Cognition Mid-life crisis Active aging New York (State) Diagnostic Imaging Centers All Other Miscellaneous Ambulatory Health Care Services Other Individual and Family Services Alzheimer's disease risk factors Risk assessment Research funding Body mass index Logistic regression analysis Descriptive statistics Walking Longitudinal method Odds ratio Mammograms Data analysis software Confidence intervals Neighborhood characteristics Sensitivity & specificity (Statistics) keyword: Alzheimer's disease body mass index procedure built environment copyrightHolder:British Geriatrics Society copyrightYear:2026 diagnosis ethnic group follow-up https://dx.doi.org/10.1093/ageing/afag054 inLanguage:en medicare middle-aged adult midlife risk factors neighborhood neighbourhood walkability older adult older people prospective nested case–control study publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41870153/ smoking women's health Alzheimer's disease body mass index procedure built environment copyrightHolder:British Geriatrics Society copyrightYear:2026 diagnosis ethnic group follow-up https://dx.doi.org/10.1093/ageing/afag054 inLanguage:en medicare middle-aged adult midlife risk factors neighborhood neighbourhood walkability older adult older people prospective nested case–control study publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41870153/ smoking women's health ab: Background The role of modifiable environmental factors in Alzheimer's disease (AD) risk remains poorly understood. Built environment features such as neighbourhood walkability (NW) may influence long-term cognitive health among women. Methods The New York University Women's Health Study recruited 14 273 cognitively healthy women aged 35–65 years between 1985 and 1991, with follow-up for over 30 years. We geocoded residential addresses for each participant to derive a validated four-item baseline NW measure and a two-item average annual NW index over the follow-up period. We conducted a nested case–control study of 1865 AD cases identified via linkage to Medicare claims during follow-up matched to 3730 controls on age, race/ethnicity and Medicare coverage using risk-set sampling. We used conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals for AD in relation to tertiles of NW measures, adjusting for potential confounders. Subgroup analyses examined potential effect modification. Results Compared with women living in areas with the lowest baseline NW, those in the middle and highest tertiles had lower odds of having a diagnosis of AD during follow-up, with an OR of 0.95 (0.82–1.11) and 0.83 (0.71–0.98), respectively (P -trend = .03). Results were similar when using average annual NW. The association did not differ appreciably by age, smoking status, education or body mass index. Conclusions Higher midlife NW was associated with reduced odds of AD later in life. These findings highlight the potential for built environment interventions to promote cognitive health and support healthy ageing in women. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|