Ageing, advanced kidney disease and the limits of prediction: what AGNES tells us about decision-making.
The article focuses on the AGing NEphropathy Study (AGNES), a prospective cohort study of Brazilian adults aged 70 and older with advanced chronic kidney disease (CKD), examining factors influencing dialysis initiation and mortality over two years. AGNES found that most very old adults with advanced...
| Publicado en: | Age & Ageing Vol. 55; no. 3; pp. 1 - 4 |
|---|---|
| Autor principal: | |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Mar2026
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192797128&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192797128 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2026 vid: 55 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192797128 10.1093/ageing/afag059 ppf: 1 ppct: 3 formats: tig: atl: Ageing, advanced kidney disease and the limits of prediction: what AGNES tells us about decision-making. aug: au: Holland, John affil: Guy's and St Thomas' Hospitals NHS Trust - Department of Transplant Surgery, Renal Medicine and Urology, London, England, United Kingdom of Great Britain and Northern IrelandKing's College London - School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, London, England, United Kingdom of Great Britain and Northern Ireland su: Health status indicators Decision making Prediction models Frail elderly Chronic kidney failure Cognition disorders Geriatric assessment Algorithms Comorbidity Phenotypes Biomarkers sug: subj: Health status indicators Decision making Prediction models Frail elderly Chronic kidney failure Cognition disorders Geriatric assessment Algorithms Comorbidity Phenotypes Biomarkers keyword: chronic kidney disease cognitive impairment comprehensive geriatric assessment copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty https://dx.doi.org/10.1093/ageing/afag059 inLanguage:en multiple long-term health conditions older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41848759/ chronic kidney disease cognitive impairment comprehensive geriatric assessment copyrightHolder:British Geriatrics Society copyrightYear:2026 frailty https://dx.doi.org/10.1093/ageing/afag059 inLanguage:en multiple long-term health conditions older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41848759/ ab: The article focuses on the AGing NEphropathy Study (AGNES), a prospective cohort study of Brazilian adults aged 70 and older with advanced chronic kidney disease (CKD), examining factors influencing dialysis initiation and mortality over two years. AGNES found that most very old adults with advanced CKD neither started dialysis nor died within this period, highlighting that progression to dialysis is not inevitable and that comorbidity burden and symptom experience, particularly excessive daytime sleepiness, play a more significant role in outcomes and treatment decisions than biomarkers or geriatric measures alone. The study emphasizes the limitations of prediction-focused models in this complex population and supports the integration of renal-tailored comprehensive geriatric assessment (CGA) to enhance shared decision-making and care planning across dialysis and transplantation pathways. These findings advocate for a shift from kidney-centric approaches toward multidimensional, geriatric-informed care in managing older adults with advanced CKD. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|