Efficacy of HMB supplementation as an adjunct to resistance training in older adults: a comprehensive meta-analysis.
Background Resistance training has robust evidence for improving muscle health in older adults; however, the additional benefit of adjunctive supplementation with β-hydroxy β-methylbutyrate (HMB) remains unclear. This systematic review and meta-analysis evaluated the effect of HMB supplementation co...
| Publicado en: | Age & Ageing Vol. 55; no. 3; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Mar2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192797138&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192797138 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2026 vid: 55 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192797138 10.1093/ageing/afag073 ppf: 1 ppct: 12 formats: tig: atl: Efficacy of HMB supplementation as an adjunct to resistance training in older adults: a comprehensive meta-analysis. aug: au: Wang, Ganyu Jawed, Inshal Tufail, Mohammad Sharaf, Mohammad Sarim Gulzar, Abu Huraira Bin Ain, Hafiza Qurat Ul Umair, Muhammad Kumar, Danaish Jabeen, Shafaq affil: Longdong University - Department of Psychology, Qingyang 745000, Gansu Province, China Dow University of Health Sciences - Department of Medicine, Karachi 74200, Sindh, Pakistan Sindh Government Hospital Karachi, Karachi 74000, Sindh, Pakistan Services Institute of Medical Sciences - Department of Medicine, Services hospital, Shadman 1 Shadman, Lahore, 40050, Lahore 54000, Pakistan CMH Multan Institute of Medical Sciences, Multan 60000, Punjab, Pakistan Dow University of Health Sciences - Department of Plastic Surgery, Karachi 74200, Sindh, Pakistan Karachi Medical and Dental College - Department of Medicine, Karachi 74700, Sindh, Pakistan su: Old age Exercise physiology Photon absorptiometry Body composition 3-Hydroxybutyric acid Treatment effectiveness Meta-analysis Descriptive statistics Resistance training Muscle strength Systematic reviews MEDLINE Medical databases Online information services Dietary supplements Evaluation sug: subj: Old age Pharmaceuticals and pharmacy supplies merchant wholesalers Food (Health) Supplement Stores Exercise physiology Photon absorptiometry Body composition 3-Hydroxybutyric acid Treatment effectiveness Meta-analysis Descriptive statistics Resistance training Muscle strength Systematic reviews MEDLINE Medical databases Online information services Dietary supplements Evaluation keyword: β-Hydroxy β-methylbutyrate body composition copyrightHolder:British Geriatrics Society copyrightYear:2026 exercise heterogeneity HMB supplementation https://dx.doi.org/10.1093/ageing/afag073 inLanguage:en muscle mass muscle strength older adult older adults older people publication bias publisher:Oxford University Press resistance training sameAs:https://pubmed.ncbi.nlm.nih.gov/41934514/ sarcopenia strength training systematic review β-Hydroxy β-methylbutyrate body composition copyrightHolder:British Geriatrics Society copyrightYear:2026 exercise heterogeneity HMB supplementation https://dx.doi.org/10.1093/ageing/afag073 inLanguage:en muscle mass muscle strength older adult older adults older people publication bias publisher:Oxford University Press resistance training sameAs:https://pubmed.ncbi.nlm.nih.gov/41934514/ sarcopenia strength training systematic review ab: Background Resistance training has robust evidence for improving muscle health in older adults; however, the additional benefit of adjunctive supplementation with β-hydroxy β-methylbutyrate (HMB) remains unclear. This systematic review and meta-analysis evaluated the effect of HMB supplementation combined with resistance training on body composition and muscle strength in adults aged 50 years and older. Methods Four databases (PubMed, Scopus, Clinicaltrials.gov , and Cochrane) were systematically searched for randomized controlled trials investigating HMB supplementation with resistance training in older adults. The main results examined fat mass, muscle mass, and muscle strength. Meta-analyses were conducted using robust variance estimation with small-sample corrections. The Cochrane RoB 2.0 tool was used to assess the risk of bias. Results A total of 561 participants were involved in 13 RCTs. According to meta-analysis data, supplementing with HMB is not advantageous concerning fat mass (SMD = 0.24, 95% CI: −0.01 to 0.49), muscle mass (SMD = 0.05, 95% CI: −0.10 to 0.20), and muscle strength (SMD = 0.04, 95% CI: −0.72 to 0.63). There was low heterogeneity for body composition outcomes but high heterogeneity for strength measures. No evidence of publication bias was detected. Conclusions The combination of HMB supplementation and resistance training does not improve body composition or muscle strength in adults aged 50 years and older. Based on the available evidence, HMB supplementation cannot be recommended as a routine adjunct to resistance training in individuals who are able to undertake structured exercise. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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