Peri-coronary inflammation and coronary microcalcification activity in subjects with diabetes mellitus; a cross-sectional analysis.
Coronary microcalcification activity (CMA) independently prognosticates cardiovascular disease risk. The relationship between dysfunctional peri-coronary adipose tissue (PCAT), a measure of local inflammation, and CMA has not been characterised in people with diabetes mellitus. Subjects with diabete...
| Publicado en: | Journal of Diabetes & its Complications Vol. 40; no. 5 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192906312&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192906312 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10568727 JIW jtl: Journal of Diabetes & its Complications issn: 10568727 maglogo: N pubinfo: dt: May2026 vid: 40 iid: 5 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 192906312 10.1016/j.jdiacomp.2026.109316 192906312 ppct: 1 formats: tig: atl: Peri-coronary inflammation and coronary microcalcification activity in subjects with diabetes mellitus; a cross-sectional analysis. aug: au: Smith, Brodie Bellinge, Brynn Francis, Roslyn J. Parry, Reece Lee, Sing Ching Bellinge, Jamie W. Schultz, Carl J. affil: Medical School, University of Queensland, 288 Herston Road, Herston, Queensland, 4006, Australia sug: ab: Coronary microcalcification activity (CMA) independently prognosticates cardiovascular disease risk. The relationship between dysfunctional peri-coronary adipose tissue (PCAT), a measure of local inflammation, and CMA has not been characterised in people with diabetes mellitus. Subjects with diabetes mellitus underwent 18F-Sodium Fluoride (18F-NaF) Positron Emission Tomography (PET) imaging and Computed Tomography (CT) coronary calcium score (CCS) imaging. Non-contrast PCAT (NC-PCAT) was quantified using the CT-value (Hounsfield Units (HU)) of the tissue adjacent to the right coronary artery. In total, 151 subjects were studied (mean age 65.4 ± 6.9, male 65.6%). Male sex (OR 2.44, 95% CI [1.17–5.05], p = 0.017), statin use (2.75 [1.09–6.89], p = 0.031), any oral antihyperglycemic use (0.43 [0.19–0.97], p = 0.043), eGFR (1.03 [1.00–1.05], p = 0.037) and the CT CCS (per 100 Agatston units, 1.17 [1.08–1.27], p < 0.001) were associated with increasing CMA. Furthermore, the NC-PCAT (per 1 HU) was positively and independently associated with increasing CMA (1.04 [1.01–1.07], p = 0.022). An NC-PCAT higher than −68.3 (N = 21) was specific for triple-vessel CMA (specificity 90%, sensitivity 47%). An elevated NC-PCAT value is independently associated with a greater CMA in people with diabetes mellitus. Further research is required to determine if NC-PCAT measures provide CVD risk stratification beyond the CT CCS. • 18F-NaF PET provides unique insights into drivers of coronary microcalcification activity in people with diabetes • PCAT can be reliably measured on non-contrast studies, and associates with measures of cardiometabolic disease • Higher NC-PCAT values associate with increased CMA burden in people with diabetes mellitus • NC-PCAT may imrprove CVD risk stratification above the CCS in people with diabetes, although further research is needed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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