Trial Enrollment Correlates in an HIV Status-Neutral mHealth Intervention Among Young Black and Latinx Men and Transgender Women Who have Sex with Men.
Young Black and Latinx men and transgender women who have sex with men (YBLMT) face persistent underrepresentation in clinical trials. This study examined the odds of study enrollment among 3327 eligible YBLMT (ages 15-29) screened between July 2020 and August 2022 for a status-neutral mHealth HIV p...
| Published in: | AIDS & Behavior Vol. 30; no. 4; pp. 1221 - 1229 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Apr2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192963557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192963557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Apr2026 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 192963557 189439766 192963557 192963557 10.1007/s10461-025-04951-0 192963557 ppf: 1221 ppct: 8 formats: tig: atl: Trial Enrollment Correlates in an HIV Status-Neutral mHealth Intervention Among Young Black and Latinx Men and Transgender Women Who have Sex with Men. aug: au: Hirshfield, S. Diaz, J. E. Lin, W. Aryal, S. Hightow-Weidman, L. B. Muessig, K. E. Bauermeister, J. A. affil: https://ror.org/0041qmd21 Department of Medicine, STAR Program, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, 11203, Brooklyn, NY, USA sug: subj: Hispanic Americans Psychosocial Factors African Americans Psychosocial Factors Men Who Have Sex With Men Psychosocial Factors Trans Women Psychosocial Factors Sexuality Telehealth HIV Infections Prevention and Control Research Subject Recruitment Clinical Trials Funding Source Human Adolescence Adult Cross Sectional Studies Odds Ratio Confidence Intervals Descriptive Statistics Educational Status Anal Intercourse HIV-Positive Persons Social Media Clinical Trial Registry Mobile Applications Age Factors Communities Support, Social Psychological Well-Being Stigma Diversity, Equity, Inclusion Bivariate Statistics Multivariate Analysis Chi Square Test Unpaired T-Tests Mann-Whitney U Test Multiple Logistic Regression Models, Statistical Data Analysis Software Adolescent: 13-18 years Adult: 19-44 years ab: Young Black and Latinx men and transgender women who have sex with men (YBLMT) face persistent underrepresentation in clinical trials. This study examined the odds of study enrollment among 3327 eligible YBLMT (ages 15-29) screened between July 2020 and August 2022 for a status-neutral mHealth HIV prevention and care intervention in the United States. Only 23% of eligible individuals enrolled. In adjusted analyses, higher education (associate's degree or higher, AOR 1.53, 95% CI 1.22–1.92), recent anal sex (AOR 1.64, 95% CI 1.10–2.43), and known HIV status (negative, AOR 1.36, 95% CI 1.02–1.82; positive, AOR 2.25, 95% CI 1.63–3.10 vs. unknown status) were associated with greater odds of enrollment. Recruitment through social media (AOR 4.41, 95% CI 3.35–5.81) and research registries or community referrals (AOR 1.93, 95% CI 1.53–2.43) resulted in higher enrollment than sexual networking apps. Younger participants (ages 15-17) had higher odds of enrolling than those aged 18-24 (AOR 1.96, 95% CI 1.06–3.70). These findings highlight the need for inclusive, community-informed recruitment strategies and suggest that perceived HIV relevance and trust in digital platforms influence enrollment. Future mHealth interventions should prioritize accessible, affirming study designs and targeted outreach to improve YBLMT engagement and representation in HIV research. Résumé: Jóvenes afroamericanos y latinos, así como mujeres transgénero que tienen sexo con hombres (YBLMT), enfrentan una persistente subrepresentación en ensayos clínicos. Este estudio examinó las probabilidades de inscripción entre 3327 YBLMT elegibles (15-29 años) evaluados entre julio de 2020 y agosto de 2022 para una intervención digital de VIH en EE. UU. Un 23% de las personas elegibles se inscribieron. En análisis ajustados, mayor educación (título técnico o superior, ORA 1.53, IC 95 % 1.22–1.92), sexo anal reciente (ORA 1.64, IC 95 % 1.10–2.43) y estado serológico conocido (negativo ORA 1.36, IC 95 % 1.02–1.82; positivo ORA 2.25, IC 95 % 1.63–3.10 vs. desconocido) se asociaron con mayor probabilidad de inscripción. El reclutamiento por redes sociales (ORA 4.41, IC 95 % 3.35–5.81) y registros de investigación o referencias comunitarias (ORA 1.93, IC 95 % 1.53–2.43) resultó más efectivo que las apps de citas. Participantes más jóvenes (15–17 años) tuvieron mayores probabilidades de inscribirse que aquellos de 18-24 (ORA 1.96, IC 95 % 1.06–3.70). Los hallazgos resaltan la necesidad de estrategias de reclutamiento inclusivas y comunitarias, y sugieren que la percepción de relevancia del VIH y la confianza en plataformas digitales influyen en la inscripción. Futuros programas mHealth deben priorizar diseños accesibles y afirmativos, y campañas dirigidas para mejorar la participación y representación de YBLMT en la investigación sobre VIH. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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