Latent Class Analysis to Explore Subtypes of EGPA: Focusing on Respiratory Involvement and Inflammation Markers.
Background/Aims: Eosinophilic granulomatosis with polyangiitis (EGPA) was regarded as a heterogeneous disease with respiratory involvement manifested in various patterns. This study aimed to explore whether subtypes with different clinical features and outcomes could be identified by latent class an...
| Publicado en: | Archives of Rheumatology Vol. 41; no. 2; pp. 81 - 93 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Aves Yayincilik A.S.
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193026606&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193026606 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 21485046 HCC5 jtl: Archives of Rheumatology issn: 21485046 maglogo: N pubinfo: dt: Apr2026 vid: 41 iid: 2 pid: 47039 pub: Aves Yayincilik A.S. artinfo: ui: 193026606 193026606 193026606 10.5152/ArchRheumatol.2025.25095 193026606 ppf: 81 ppct: 12 formats: tig: atl: Latent Class Analysis to Explore Subtypes of EGPA: Focusing on Respiratory Involvement and Inflammation Markers. aug: au: Gu, Yu Liu, Yitong Zhang, Ting Han, Yang Peng, Min Shi, Juhong affil: Department of Pulmonary and Critical Care Medicine, Capital Medical University, Beijing Anzhen Hospital, Beijing, China sug: subj: Churg-Strauss Syndrome Classification Respiratory Tract Diseases Complications Inflammation Mediators Blood Human Male Female Adult Middle Age Aged Structural Equation Modeling Disease Progression Patient Classification Prognosis Survival Rate Retrospective Design Record Review Prospective Studies Antibodies, Antineutrophil Cytoplasmic Asthma Bronchiectasis Forced Expiratory Volume C-Reactive Protein Blood Sedimentation Descriptive Statistics Data Analysis Software T-Tests Mann-Whitney U Test Chi Square Test kappa Statistic Kaplan-Meier Estimator Cox Proportional Hazards Model Log-Rank Test Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background/Aims: Eosinophilic granulomatosis with polyangiitis (EGPA) was regarded as a heterogeneous disease with respiratory involvement manifested in various patterns. This study aimed to explore whether subtypes with different clinical features and outcomes could be identified by latent class analysis (LCA) from the perspective of the respiratory system in patients with EGPA. Materials and Methods: Patients diagnosed with EGPA between January 2000 and December 2022 were included. The clinical data and survival of the individuals were collected. Subtypes were identified using LCA according to organ involvement and anti-neutrophil cytoplasmic antibody (ANCA) status in model 1, according to patterns of respiratory involvement, other organ involvement, ANCA status, and inflammatory markers in model 2. The characteristics and prognosis of the classes were compared. Results: Out of the 330 patients initially diagnosed with EGPA, 245 patients were included eventually. In model 1, 138 (56.3%) and 107 (43.7%) patients were identified in classes 1 and 2, respectively. Class 2 was older (P=.017), had less musculoskeletal, mucocutaneous, cardiovascular, gastrointestinal, and peripheral nervous involvement (all P < .001) compared to class 1. No significant difference in overall survival was found between the classes. In model 2, LCA assigned 165 (67.3%) participants to class 1 (systemic EGPA) and 80 (32.7%) to class 2 (respiratory-limited EGPA). Compared with class 1, class 2 was younger (P < .001) and had lower levels of inflammation markers (white blood cell, eosinophil, erythrocyte sedimentation rate, and C-reactive protein: P < .001). Besides, patients in class 2 were more likely to have airway involvement, including the onset of asthma (P=.041), FEV1/FVC < 70% (P < .001), and bronchiectasis (P < .001). Moreover, class 2 exhibited better survival compared to class 1 (P=.001). Conclusion: The respiratory-limited EGPA may be the relatively milder type of disease. Other organ functions, serum inflammatory markers, and ANCA should be monitored during follow-up in these patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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