Preclinical Evaluation of a Zinc Oxide Nanoparticle–Loaded Amniotic Membrane as a Bioactive Scaffold for Partial‐Thickness Burn Healing in Rats.
Burn wound infections continue to be a leading cause of morbidity and mortality despite advancements in medical treatments. Human amniotic membrane and zinc oxide nanoparticles have individually shown promise in enhancing wound healing. This study evaluated the efficacy of a novel composite scaffold...
| Publicado en: | BioMed Research International Vol. 2026; pp. 1 - 13 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/23/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193257912&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193257912 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/23/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 193257912 193257912 193257912 10.1155/bmri/7362331 193257912 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Preclinical Evaluation of a Zinc Oxide Nanoparticle–Loaded Amniotic Membrane as a Bioactive Scaffold for Partial‐Thickness Burn Healing in Rats. aug: au: Hashemi, Seyedeh-Sara Mohammadi, Ali-Akbar Jalali, Seyed Behzad Mosalamiaghili, Seyedarad Rafati, Alireza Ghaedi, Mojtaba De Molon, Rafael Scaf affil: Burn and Wound Healing Research Center,, Shiraz University of Medical Sciences,, Shiraz, Iran, sums.ac.ir sug: subj: Burns Therapy Zinc Oxide Therapeutic Use Nanoparticles Amnion Wound Healing Physiology Tissue Scaffolds Methods Treatment Outcomes Animal Studies Rats Iran Models, Biological Fibroblasts Cell Proliferation Cell Viability Microscopy, Electron, Scanning Spectrometry, X-Ray Emission Cell Culture Techniques Flow Cytometry Tissue Engineering Biocompatible Materials One-Way Analysis of Variance Post Hoc Analysis Statistical Significance Data Analysis Software Descriptive Statistics ab: Burn wound infections continue to be a leading cause of morbidity and mortality despite advancements in medical treatments. Human amniotic membrane and zinc oxide nanoparticles have individually shown promise in enhancing wound healing. This study evaluated the efficacy of a novel composite scaffold made of zinc oxide nanoparticles–impregnated human amniotic membrane for treating second‐degree burn wounds. Human amniotic membrane was isolated from cesarean‐delivered placentas and loaded with nanoparticles via ultrasonic dispersion. The composite scaffold was characterized using scanning electron microscopy and energy‐dispersive x‐ray spectroscopy, which confirmed uniform nanoparticle distribution. Human fibroblast cell culture studies demonstrated enhanced cell viability and adhesion in the composite scaffold compared with controls. In a rat model of second‐degree burns, the nZnO‐impregnated human amniotic membrane significantly improved wound healing, evidenced by faster reepithelialization, reduced inflammation, and complete tissue regeneration by Day 14. These findings suggest that the combination of nZnO and human amniotic membrane offers superior wound healing properties over traditional treatments, with potential applications for burn care. Future studies should explore human trials to further validate the clinical potential of this novel approach. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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