Group‐Based Medical Mistrust and Logistical Factors Influencing Rheumatology Clinical Trial Enrollment: A Single‐Center Cross‐Sectional Survey.
Objective: To examine whether group‐based medical mistrust predicts willingness to enroll in a rheumatology clinical trial and, among those unwilling, to identify logistical factors that most influence their decision. Methods: We conducted a single‐center, cross‐sectional survey at an academic rheum...
| Publicado en: | ACR Open Rheumatology Vol. 8; no. 4; pp. 1 - 8 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193323291&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193323291 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25785745 LXGC jtl: ACR Open Rheumatology issn: 25785745 maglogo: N pubinfo: dt: Apr2026 vid: 8 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 193323291 193323291 193323291 10.1002/acr2.90030 193323291 ppf: 1 ppct: 7 formats: tig: atl: Group‐Based Medical Mistrust and Logistical Factors Influencing Rheumatology Clinical Trial Enrollment: A Single‐Center Cross‐Sectional Survey. aug: au: Martinez Paulino, Andreina Arias Diaz, Danny Jose King, Miles Cheema, Asma Wang, Shudan Marian, Valentin Savel, Richard Khawaja, Muznay affil: Rutgers University and Robert Wood Johnson Barnabas Health, Jersey City New Jersey sug: subj: Medical Mistrust Rheumatology Research Subject Recruitment Clinical Trials Patient Attitudes Evaluation Ethnic Groups Motivation Human New Jersey Female Male Adolescence Adult Middle Age Aged Cross Sectional Studies Academic Medical Centers Scales Electronic Health Records Record Review Regression Univariate Statistics Odds Ratio Confidence Intervals Logistic Regression T-Tests Pearson's Correlation Coefficient Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective: To examine whether group‐based medical mistrust predicts willingness to enroll in a rheumatology clinical trial and, among those unwilling, to identify logistical factors that most influence their decision. Methods: We conducted a single‐center, cross‐sectional survey at an academic rheumatology clinic between November 2024 and February 2025. Adults (≥18 years) with physician‐confirmed rheumatic disease completed the 12‐item Group‐Based Medical Mistrust Scale (GBMMS; range 12–60, higher = more mistrust), rated 11 logistical factors on a 7‐point scale (1 = extremely unlikely to influence, 7 = extremely likely), and answered a yes or no item on trial willingness. We assessed GBMMS internal consistency, compared mean mistrust by willingness using Welch's t‐test, and fit a univariable logistic regression with GBMMS predicting willingness. Among those unwilling, we ranked logistical factors by mean importance. Results: Forty‐seven patients participated (79% women; mean age 49.2 ± 13.6 years); 66% reported willingness to enroll. Mean mistrust did not differ by willingness (willing 24.7 ± 11.6 vs unwilling 25.3 ± 13.4; t26 = 0.13, P = 0.893), and GBMMS did not predict willingness (odds ratio 0.996, 95% confidence interval 0.95–1.05; P = 0.89). Among the 16 patients unwilling to participate, the highest‐rated influences were the prospect of stopping disease progression (mean 5.38), physician encouragement (mean 4.56), travel or transportation (mean 4.13), and shared language with the doctor (mean 4.13). Conclusion: Group‐based medical mistrust did not predict self‐reported willingness to join a rheumatology clinical trial. Instead, expectation of concrete disease improvement and personal endorsement by one's treating rheumatologist emerged as the strongest drivers of participation. Recruitment strategies that emphasize realistic potential benefits, incorporate physician‐delivered invitations, and address logistics may improve enrollment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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