Amyloid beta pathology induces astrocytic pTDP-43 mislocalization and disrupts TDP-43-regulated cryptic exon transcripts.
Background: While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer's disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mis...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 12 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |