GLP-1 Weight Loss Protocol: An Evidence-Based Translation Project.

Background: Obesity is a prevalent chronic disease associated with many comorbidities and increased mortality rates. Primary care providers are critical in addressing obesity through an evidence-based weight loss protocol. Objective: This Doctor of Nurse Practice project aimed to develop and impleme...

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Publicado en:Journal of Doctoral Nursing Practice Vol. 19; no. 1; pp. 75 - 85
Autor principal: Allred, Meghan
Formato: research tables/charts Journal Article
Publicado: Springer Publishing Company, Inc. 2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2026
      vid: 19
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      pub: Springer Publishing Company, Inc.
      place: New York, New York
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        193368232
        193368232
        193368232
        10.1891/JDNP-2024-0021
        193368232
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        atl: GLP-1 Weight Loss Protocol: An Evidence-Based Translation Project.
      aug:
        au: Allred, Meghan
        affil: Department of Nursing, Baylor University, Waco, TX, USA
      sug:
        subj:
          Glucagon-Like Peptide 1 Therapeutic Use
          Weight Control
          Quality Improvement
          Nursing Protocols
          Motivational Interviewing
          Obesity Therapy
          Nursing Practice, Evidence-Based
          Human
          Body Mass Index
          Texas
          Ambulatory Care Facilities Texas
          Body Weight
          Blood Pressure
          Paired T-Tests
          Descriptive Statistics
          Functional Status
          Self Concept
          Questionnaires
          Diastolic Pressure
          Quality of Life
          Patient Centered Care
          Advanced Practice Registered Nurses
      ab: Background: Obesity is a prevalent chronic disease associated with many comorbidities and increased mortality rates. Primary care providers are critical in addressing obesity through an evidence-based weight loss protocol. Objective: This Doctor of Nurse Practice project aimed to develop and implement a standardized, evidence-based holistic weight loss protocol, incorporating glucagon-like peptide-1 (GLP-1) medication, semaglutide, and motivational interviewing within a patient-centered framework. Methods: In this quality improvement project, 10 nondiabetic participants with a body mass index (BMI) ≥ 27 kg/m² were recruited from a suburban clinic in Cypress, TX. Data such as body weight, BMI, and blood pressure were collected in addition to Impact of Weight on Quality of Life-Lite (IWQOL-Lite) survey responses. Data were then analyzed in Excel using the paired t test with statistical significance being <.05. Results: Participants lost a significant amount of weight (p <.05) and had a significant decrease in BMI (p <.05). Postintervention physical function, self-esteem, and work-related experiences improved significantly (p <.05) based on the IWQOL questionnaire pre- and postintervention. Diastolic blood pressure also significantly decreased (p <.05). Conclusions: This weight loss protocol, guided by evidence-based practice alongside GLP-1 medication, semaglutide, revealed positive outcomes in weight reduction, BMI, and quality of life. This protocol offers providers a promising approach to managing obesity in primary care settings. Implications for Nursing: Implementing this evidence-based weight loss protocol can empower advanced practice nurses (APRNs) to address obesity effectively. Motivational interviewing, holistic patient-centered care, ongoing support, and education are critical features to sustaining weight loss for obese patients. This protocol provides a structured approach for APRNs in guiding nondiabetic overweight and obese patients toward sustainable weight loss.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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