Effect of a Combined Antidepressant Drug Flupentixol–Melitracen on Glucose Level and Expression of Insulin‐Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.
The number of depression sufferers is increasing at an alarming rate around the world. As a result, the usage of antidepressant drugs is growing day by day. However, the effect of this medication on glucose homeostasis is not clear. We investigated the impact of a combined antidepressant drug flupen...
| Publicado en: | BioMed Research International Vol. 2026; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/30/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193399297&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193399297 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/30/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 193399297 193399297 193399297 10.1155/bmri/6698526 193399297 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Effect of a Combined Antidepressant Drug Flupentixol–Melitracen on Glucose Level and Expression of Insulin‐Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster. aug: au: Barkat, Azizul Islam Ahmed, Khandaker Asif Akter, Sumaiya Shamsudduha, Md Riana, Farhin Momtaz Mehe Jabin, Rabeya Bosri Begum, Mahmuda Alam, Mohammad Shamimul Ortega, Arturo affil: Genetics and Molecular Biology Laboratory,, Department of Zoology,, University of Dhaka,, Dhaka, Bangladesh, du.ac.bd sug: subj: Antidepressive Agents Pharmacodynamics Blood Glucose Drug Effects Insects Drug Effects Gene Expression Drug Effects Somatomedins Drug Effects Drug Combinations Pharmacodynamics Treatment Outcomes Evaluation Animal Studies Insects Models, Biological Bangladesh Linear Regression Drug Compounding Bioinformatics Polymerase Chain Reaction Data Analysis Software Wilcoxon Rank Sum Test RNA, Messenger Spectrophotometry Toxicity Tests Sequence Analysis Larva Physiology Funding Source ab: The number of depression sufferers is increasing at an alarming rate around the world. As a result, the usage of antidepressant drugs is growing day by day. However, the effect of this medication on glucose homeostasis is not clear. We investigated the impact of a combined antidepressant drug flupentixol‐melitracen on glucose levels and the expression of associated genes in Drosophila melanogaster. The flies were reared in control and treatment vials having standard and drug‐treated food. The glucose oxidase method showed significantly reduced glucose levels in the treated Drosophila. The Ct values obtained from qPCR for the relative quantification of Drosophila insulin‐like peptide (DILP) genes, DILP5 and DILP6, were analyzed using the 2−ΔΔCT method. The DILP5 gene was expressed slightly higher in the antidepressant‐treated group, though the expressions of the DILP genes appeared statistically insignificant. The current study suggests that anxiolytics and antidepressant drugs might be associated with the insulin signaling pathway, which is crucial for growth, glucose regulation, and other fundamental metabolic processes. Further study is required to determine the expression pattern of all DILP and other genes that might affect glucose homeostasis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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