Clinical progression of a smallpox postvaccination response.
Abstract\nKEY POINTSWe present the case of a 20-year-old man with a non-necrotic, shallow, well-circumscribed ulcer on the shoulder. The patient had no significant medical history, although he noted that he was joining the military and received a smallpox vaccine injection at the same site several w...
| Publicado en: | Baylor University Medical Center Proceedings pp. 1 - 4 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193452253&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193452253 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08998280 1XEP jtl: Baylor University Medical Center Proceedings issn: 08998280 maglogo: N pubinfo: dt: Apr2026 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 193452253 10.1080/08998280.2026.2661295 193452253 ppf: 1 ppct: 3 formats: tig: atl: Clinical progression of a smallpox postvaccination response. aug: au: Zhou, Maggie H. Lipner, Shari R. Tyring, Stephen K. affil: Vagelos College of Physicians and Surgeons, Columbia University sug: ab: Abstract\nKEY POINTSWe present the case of a 20-year-old man with a non-necrotic, shallow, well-circumscribed ulcer on the shoulder. The patient had no significant medical history, although he noted that he was joining the military and received a smallpox vaccine injection at the same site several weeks earlier. While the differential diagnosis also included pyoderma gangrenosum, brown recluse bite, and Buruli ulcer, the patient’s presentation is characteristic of a typical postvaccination progression, which is self-limited. It is important for dermatologists for be aware of this postvaccination response to avoid misdiagnosis and unnecessary workup, given that the smallpox vaccine is still administered in healthcare workers and military recruits.A typical smallpox postvaccination response may appear as a papule at the inoculation site (days 3–4), progressing to a vesicle with surrounding erythema and ulceration (days 5–6). Scabs may form by days 7 to 8.Isolated ulceration at a prior inoculation site should prompt consideration of smallpox vaccination response, particularly in military or healthcare personnel, as this history alone may establish the diagnosis.Systemic symptoms, nonhealing ulcers, and generalized cutaneous involvement are key features that distinguish rare vaccine-related complications from the expected localized reaction.Prompt recognition of characteristic postvaccination progression can reduce misdiagnosis and unnecessary workup. pubtype: Academic Journal doctype: Journal Article ougenre: Unknown language: English refInfo: holdings: @attributes: islocal: N |
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