Oxidative stress mediates the association between brominated flame retardants and hyperlipidemia in US adults.
Brominated flame retardants (BFRs) are classified as persistent organic pollutants (POPs), and studies suggest that exposure to POPs may contribute to the development of metabolic diseases. However, the specific link between single and mixed BFRs and hyperlipidemia remains unclear, as does the poten...
| Publicado en: | International Journal of Environmental Health Research Vol. 36; no. 5; pp. 877 - 889 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193489433&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193489433 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: May2026 vid: 36 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 193489433 187404403 193489433 193489433 10.1080/09603123.2025.2548905 193489433 ppf: 877 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Oxidative stress mediates the association between brominated flame retardants and hyperlipidemia in US adults. aug: au: Li, Xiaodong Liao, Juan Chen, Zhenhua Wang, Hao Long, Lu affil: Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China sug: subj: Oxidative Stress Hyperlipidemia Chemically Induced Flame Retardants Adverse Effects Environmental Exposure Adverse Effects Environmental Pollutants Adverse Effects Hydrocarbons, Brominated Adverse Effects Hyperlipidemia Risk Factors Risk Assessment Human Male Female Adult Middle Age Funding Source United States Cross Sectional Studies Nutritional Assessment Prevalence Multiple Logistic Regression Dose-Response Relationship Cholesterol Blood Triglycerides Blood Lipoproteins, LDL Cholesterol Blood gamma-Glutamyltransferase Blood Biological Markers Blood Gas Chromatography-Mass Spectrometry Descriptive Statistics Spearman's Rank Correlation Coefficient Multiple Regression Mediation Analysis Antilipemic Agents Therapeutic Use Odds Ratio Confidence Intervals Epigenomics Peroxisome Proliferator-Activated Receptors Drug Effects Gut Microbiota Drug Effects Probability Sample Health Status Nutritional Status Lipoproteins, HDL Blood T-Tests Mann-Whitney U Test Chi Square Test Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Brominated flame retardants (BFRs) are classified as persistent organic pollutants (POPs), and studies suggest that exposure to POPs may contribute to the development of metabolic diseases. However, the specific link between single and mixed BFRs and hyperlipidemia remains unclear, as does the potential mediating role of oxidative stress in this relationship. We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2016, encompassing 6800 participants, to investigate the association between BFRs and hyperlipidemia. Our findings from weighted multiple logistic regression models suggest that PBB153 and PBDE28 are significantly associated with hyperlipidemia. Furthermore, both the weighted quantile sum (WQS) regression model and the quantile g-computation (QGcomp) model demonstrated a positive association between mixed BFRs exposure and hyperlipidemia. Additionally, we revealed positive associations between individual and combined BFRs and levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). Furthermore, the oxidative stress marker γ-glutamyltransferase (GGT) plays a mediating role in the relationship between BFRs and hyperlipidemia, TC and TG. Our study concludes that BFRs are associated with an increased prevalence of hyperlipidemia and lipid levels, with oxidative stress likely acting as a mediator in this process. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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