The assessment of the fibrinogen-to-platelet ratio for predicting mortality of COVID-19 in non-diabetic subjects.
Little is known about the biomarkers of mortality in SARS-CoV-2-infected patients without a previous diagnosis of diabetes. Thus, this study aimed to assess the fibrinogen-to-platelet ratio (FPR) and compare its predictive value with the main biomarkers for COVID-19 mortality, such as neutrophil-to-...
| Publicado en: | International Journal of Environmental Health Research Vol. 36; no. 5; pp. 1036 - 1046 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193489445&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193489445 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: May2026 vid: 36 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 193489445 187806233 193489445 193489445 10.1080/09603123.2025.2557428 193489445 ppf: 1036 ppct: 10 formats: tig: atl: The assessment of the fibrinogen-to-platelet ratio for predicting mortality of COVID-19 in non-diabetic subjects. aug: au: Reyes-Ruiz, José Manuel Ríos-Ríos, Monserratte Martínez-Mier, Gustavo affil: Department of Research, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Veracruz, Mexico sug: subj: COVID-19 Mortality Hospital Mortality Risk Factors Fibrinogen Blood Platelet Count Biological Markers Blood Risk Assessment Predictive Value of Tests Human Nonexperimental Studies Retrospective Design Prospective Studies Record Review Mexico Neutrophils Neutrophil Lymphocyte Ratio Descriptive Statistics ROC Curve Confidence Intervals Cox Proportional Hazards Model Platelet Lymphocyte Ratio Lactate Dehydrogenase Blood Tertiary Health Care Mann-Whitney U Test Chi Square Test Fisher's Exact Test T-Tests Kaplan-Meier Estimator Log-Rank Test Univariate Statistics Multivariate Statistics Data Analysis Software Male Female Middle Age Aged Inpatients Adult Leukocyte Count Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Little is known about the biomarkers of mortality in SARS-CoV-2-infected patients without a previous diagnosis of diabetes. Thus, this study aimed to assess the fibrinogen-to-platelet ratio (FPR) and compare its predictive value with the main biomarkers for COVID-19 mortality, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), leukocyte glucose index (LGI), and lactate dehydrogenase (LDH)/lymphocyte ratio. This retrospective cohort study in a population of Mexico included 70 non-diabetic patients with COVID-19 from 1 May 2020 to 30 September 2020. Non-survivors (n = 25) had higher leukocytes (p = 0.004), neutrophils (p = 0.003), FPR (p < 0.0001), and NLR (p = 0.006) values in comparison with survivors (n = 45). Area Under the Curve (AUC) of FPR (AUC = 0.71) was higher than for NLR (AUC = 0.69). Cox regression analysis revealed that FPR > 34.2 (Hazard Ratio (HR) = 2.05, 95% confidence interval (CI) 1.39–3.03, Pcorrected = 0.0009) was an independent predictor for COVID-19 mortality. Our findings suggest that FPR levels on admission greater than 34.2 could effectively predict the mortality of SARS-CoV-2-infected patients without a previous diagnosis of diabetes. In contrast, the main known biomarkers of COVID-19 mortality, such as NLR, PLR, LGI, PAFI ratio, and LDH/lymphocyte ratio, were irrelevant in this study. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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