Antidepressants and risk of pneumonia in older adults: a nationwide self-controlled case series.
Background Pneumonia is a leading cause of morbidity and mortality in older adults, and antidepressant use is increasing globally. Although biologically plausible links exist, comprehensive, population-based evidence remains limited. We evaluated the association of antidepressant use with pneumonia...
| Publicado en: | Age & Ageing Vol. 55; no. 4; pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500072&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500072 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500072 10.1093/ageing/afag070 ppf: 1 ppct: 10 formats: tig: atl: Antidepressants and risk of pneumonia in older adults: a nationwide self-controlled case series. aug: au: Jeon, Jinyoung Geum, Min Jung Ah, Young-Mi Lee, Hyun Woo Yu, Yun Mi affil: Department of Pharmaceutical Medicine and Regulatory Science, Yonsei University Colleges of Medicine and Pharmacy, Incheon 21983, the Republic of KoreaDepartment of Pharmacy, National Cancer Center Hospital, Goyang-si 10408, the Republic of Korea College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan-si, Gyeonggi-do 15588, the Republic of Korea College of Pharmacy, Yeungnam University, Gyeongsan-si 38541, the Republic of Korea Department of Pharmaceutical Medicine and Regulatory Science, Yonsei University Colleges of Medicine and Pharmacy, Incheon 21983, the Republic of Korea Department of Pharmaceutical Medicine and Regulatory Science, Yonsei University Colleges of Medicine and Pharmacy, Incheon 21983, the Republic of KoreaDepartment of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University College of Pharmacy, Incheon 21983, the Republic of Korea su: South Korea Hospital care Age distribution Stroke Pneumonia Risk assessment Parasympathomimetic agents Poisson distribution Neurologic manifestations of general diseases Frail elderly Parkinson's disease Antidepressants Longitudinal method Health outcome assessment Confidence intervals Dementia Data analysis software Drug utilization Comorbidity Disease progression Regression analysis sug: subj: Hospital care Age distribution Stroke South Korea Pharmaceutical and medicine manufacturing Medicinal and Botanical Manufacturing Pneumonia Risk assessment Parasympathomimetic agents Poisson distribution Neurologic manifestations of general diseases Frail elderly Parkinson's disease Antidepressants Longitudinal method Health outcome assessment Confidence intervals Dementia Data analysis software Drug utilization Comorbidity Disease progression Regression analysis keyword: anticholinergic agents antidepressants antidepressive agents comorbidity copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag070 inLanguage:en older adult older adults pneumonia publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41947568/ sedatives self-controlled case series anticholinergic agents antidepressants antidepressive agents comorbidity copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag070 inLanguage:en older adult older adults pneumonia publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41947568/ sedatives self-controlled case series ab: Background Pneumonia is a leading cause of morbidity and mortality in older adults, and antidepressant use is increasing globally. Although biologically plausible links exist, comprehensive, population-based evidence remains limited. We evaluated the association of antidepressant use with pneumonia hospitalisation and potential effect modifiers. Methods We conducted a nationwide self-controlled case series using Korea National Health Insurance Service–Senior Cohort data on adults aged 60–80 years who initiated antidepressants and were hospitalised for pneumonia (2008–2019). The risk period was defined as 90 days (three 30-day intervals) after antidepressant initiation, with baseline periods as the reference. Incidence rate ratios (IRRs) were calculated using conditional Poisson regression adjusted for age and season. Subgroup analyses were performed according to demographics, comorbidities, and the anticholinergic/sedative burden. Results Among 15,478 individuals, pneumonia hospitalisation risk was higher during the 90-day risk period (IRR 2.48, 95% CI 2.35–2.61), peaking in the first 30 days (IRR 3.53, 95% CI 3.31–3.76). Risk remained elevated in later intervals and declined during washout. Stronger associations were observed in older age and neurologic comorbidities. A graded pattern by pharmacological burden showed the highest risk in those with both high anticholinergic and sedative loads. Conclusion Antidepressant use was associated with an increased pneumonia hospitalisation in older adults. The risk was further elevated in patients with neurologic conditions or a high anticholinergic/sedative burden, highlighting the need for individualised prescriptions and routine medication reviews. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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