Barriers and facilitators to recruiting older adult care home residents into clinical trials of medicines and vaccines: a scoping review.
Introduction Excluding Care Home (CH) residents from clinical trials of medicines and vaccines has led to an evidence gap. Findings from younger adults may not be generalisable to CH residents with frailty and dementia. Therefore, it is essential to evaluate pharmacological treatments directly in CH...
| Publicado en: | Age & Ageing Vol. 55; no. 4; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500075&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500075 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500075 10.1093/ageing/afag077 ppf: 1 ppct: 12 formats: tig: atl: Barriers and facilitators to recruiting older adult care home residents into clinical trials of medicines and vaccines: a scoping review. aug: au: Subbarayan, Selvarani Smith-Dodd, Imogen Nicolson, Gabriel Burton, Jennifer K Scott, Janet T Vasan, Seshadri S Shenkin, Susan D Soiza, Roy L Consortium, The WATCH affil: Ageing Clinical and Experimental Research Group, The Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UKAberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK Ageing Clinical and Experimental Research Group, The Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK Academic Geriatric Medicine, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK Research, Development and Innovation, NHS Highland, Inverness, UKSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UKCentre for Virus Research, University of Glasgow, Glasgow, UK Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UKSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia Ageing and Health, and Advanced Care Research Centre, Usher Institute, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK su: Health services accessibility Patient-professional relations Drugs Health facilities Patient selection Medical information storage & retrieval systems CINAHL database Systematic reviews MEDLINE Medical databases Attitudes of medical personnel Vaccines Psychology information storage & retrieval systems sug: subj: Health services accessibility Patient-professional relations Drugs Health facilities Pharmaceutical and medicine manufacturing Drugs and Druggists' Sundries Merchant Wholesalers Pharmaceuticals and pharmacy supplies merchant wholesalers All Other Outpatient Care Centers Patient selection Medical information storage & retrieval systems CINAHL database Systematic reviews MEDLINE Medical databases Attitudes of medical personnel Vaccines Psychology information storage & retrieval systems keyword: barriers and facilitators care home residents care homes copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag077 inLanguage:en internship and residency medical residencies nursing homes older adult older people pharmacotherapy publisher:Oxford University Press randomised controlled trials sameAs:https://pubmed.ncbi.nlm.nih.gov/41965248/ vaccine trials vaccines barriers and facilitators care home residents care homes copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag077 inLanguage:en internship and residency medical residencies nursing homes older adult older people pharmacotherapy publisher:Oxford University Press randomised controlled trials sameAs:https://pubmed.ncbi.nlm.nih.gov/41965248/ vaccine trials vaccines ab: Introduction Excluding Care Home (CH) residents from clinical trials of medicines and vaccines has led to an evidence gap. Findings from younger adults may not be generalisable to CH residents with frailty and dementia. Therefore, it is essential to evaluate pharmacological treatments directly in CH residents to assess their safety and efficacy. Methods As part of the Widening Access to Trials in Care Homes project, we conducted a scoping review using Joanna Briggs Institute methodology to identify barriers and facilitators to recruiting CH residents into clinical trials of medicinal products. We searched EMBASE, MEDLINE, PsycINFO, CINAHL, and the Cochrane Library (1990 to January 2025). Quantitative data on screen failures and dropouts, and qualitative data on trial teams' real-world experiences and stakeholder perspectives were extracted, synthesised into themes and presented as descriptive summaries. Results From 14,301 records, eight articles were included (2002 to 2021) from the USA (N = 4), UK (N = 3) and France (N = 1). Six were RCTs, and two were a qualitative sub-study and a questionnaire survey. Screen failure rates ranged from 18% to 96%. Identified themes of barriers and facilitators were study design, selection criteria, recruitment methods, data collection methods, participant retention, CH resident and family-related factors, CH facility and staff-related factors, healthcare professional involvement, logistical and operational factors, consent-related factors, ethical and regulatory considerations, insurance and trial costs, and generalisability of trial results. Conclusions Our review specifically identified key barriers and facilitators to recruiting CH residents into pharmacological trials. These findings can guide trial planning and support evidence-based care for this vulnerable population. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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