Muscle mass, function and performance across the adult lifespan: the study of muscle, mobility and ageing.
Background D-creatine (DCr) dilution provides an accurate estimate of total body skeletal muscle mass, yet few studies have examined its relationship with function and performance across the lifespan, particularly before age 70. We modelled the association of age with D₃Cr muscle mass across adultho...
| Publicado en: | Age & Ageing Vol. 55; no. 4; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500084&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500084 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500084 10.1093/ageing/afag088 ppf: 1 ppct: 10 formats: tig: atl: Muscle mass, function and performance across the adult lifespan: the study of muscle, mobility and ageing. aug: au: Hetherington-Rauth, Megan McCulloch, Charles E Kritchevsky, Stephen B Newman, Anne B Hepple, Russel T Coen, Paul M Goodpaster, Bret H Shankaran, Mahalakshmi Hellerstein, Marc Evans, William J affil: California Pacific Medical Center Research Institute, San Francisco, CA 91740, USA Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA Department of Internal Medicine, Wake Forest University, Winston-Salem, NC 27104, USA Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA Translational Research Institute for Metabolism and Diabetes, AdventHealth Orlando, Orlando, FL 32803, USA Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA su: Cross-sectional method Sex distribution Age distribution Aging Longevity Skeletal muscle physiology Biomechanics Cardiopulmonary fitness Leg Research funding Magnetic resonance imaging Muscle strength testing Descriptive statistics Muscle strength Thigh Body movement Oxygen consumption Walking speed Data analysis software Physical mobility Regression analysis sug: subj: Cross-sectional method Sex distribution Age distribution Aging Longevity Diagnostic Imaging Centers Skeletal muscle physiology Biomechanics Cardiopulmonary fitness Leg Research funding Magnetic resonance imaging Muscle strength testing Descriptive statistics Muscle strength Thigh Body movement Oxygen consumption Walking speed Data analysis software Physical mobility Regression analysis keyword: adult aerobic capacity ageing aging copyrightHolder:British Geriatrics Society copyrightYear:2026 creatine https://dx.doi.org/10.1093/ageing/afag088 inLanguage:en leg life span magnetic resonance imaging maximum oxygen uptake mobility muscle function muscle mass older adult older people power publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41965250/ skeletal muscles strength thigh muscle walking speed adult aerobic capacity ageing aging copyrightHolder:British Geriatrics Society copyrightYear:2026 creatine https://dx.doi.org/10.1093/ageing/afag088 inLanguage:en leg life span magnetic resonance imaging maximum oxygen uptake mobility muscle function muscle mass older adult older people power publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41965250/ skeletal muscles strength thigh muscle walking speed ab: Background D-creatine (DCr) dilution provides an accurate estimate of total body skeletal muscle mass, yet few studies have examined its relationship with function and performance across the lifespan, particularly before age 70. We modelled the association of age with D₃Cr muscle mass across adulthood and compared it with age-related differences in muscle function and performance. Methods Adults aged 30–69 years (n = 69; 33 men) and 70+ (n = 826; 344 men) from the Study of Muscle, Mobility and Ageing completed assessments of DCr muscle mass, magnetic resonance imaging (MRI) thigh muscle volume, 1-RM leg strength and leg extension power, 4 m walking speed and cardiorespiratory fitness (VO peak). Regression models estimated annualised percent differences with age for each outcome. Results In men, progressively lower D₃Cr muscle mass with advancing age (−0.5%/year in young adults to −1.4%/year in oldest-old) paralleled the pattern observed for leg strength and walking speed (P > .05). Larger age-associated differences were observed for leg power and VO₂ peak, and smaller for MRI thigh muscle volume. In women, D₃Cr muscle mass was already lower in young adulthood (−0.6%/year) and remained relatively stable thereafter, a pattern similar to MRI thigh muscle volume. However, age-related differences in strength, power and VO₂ peak in women generally exceeded those in D₃Cr muscle mass, while walking speed aligned more closely. Conclusion Age-associated differences in muscle mass tracked closely with strength (men) and functional capacity. These results indicate that the role of low muscle mass in functional decline has been underestimated, emphasising the importance of strategies to preserve/enhance muscle mass throughout adulthood. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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