Prostate ageing across the adult lifespan: population MRI evidence from 30 000 men.
Background Prostate enlargement and lower urinary tract symptoms are common age-related conditions in men frequently encountered in primary care and geriatric medicine practice, yet population-level variation in prostate size and its biological drivers remain poorly defined due to limited scalable i...
| Publicado en: | Age & Ageing Vol. 55; no. 4; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500086&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500086 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500086 10.1093/ageing/afag090 ppf: 1 ppct: 8 formats: tig: atl: Prostate ageing across the adult lifespan: population MRI evidence from 30 000 men. aug: au: Kordes, Gunnar P Schwarzkopf, Vanessa Ogoniak, Lynn Brücher, Benedict Busch, Alexander S affil: Department of General Pediatrics, University Hospital Münster, Münster, Germany Institute of Medical Informatics, University of Münster, Münster, Germany Department of Urology, University Hospital Münster, Münster, Germany su: United Kingdom Uk Biobank Ltd. Cross-sectional method Stature Aging Disease risk factors Reference values Testosterone Risk assessment Body mass index Prostate-specific antigen Research funding Multiple regression analysis Logistic regression analysis Magnetic resonance imaging Multivariate analysis Descriptive statistics Prostate Benign prostatic hyperplasia Longitudinal method Somatomedin Bioavailability Urination disorders Automation Confidence intervals Data analysis software Biomarkers Disease complications sug: subj: Cross-sectional method Stature Aging Disease risk factors United Kingdom Uk Biobank Ltd. Diagnostic Imaging Centers Reference values Testosterone Risk assessment Body mass index Prostate-specific antigen Research funding Multiple regression analysis Logistic regression analysis Magnetic resonance imaging Multivariate analysis Descriptive statistics Prostate Benign prostatic hyperplasia Longitudinal method Somatomedin Bioavailability Urination disorders Automation Confidence intervals Data analysis software Biomarkers Disease complications keyword: adult aging copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag090 inLanguage:en lower urinary tract symptoms magnetic resonance imaging MRI older adult older people organ ageing population study prostate prostate ageing prostate volume publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41965253/ adult aging copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag090 inLanguage:en lower urinary tract symptoms magnetic resonance imaging MRI older adult older people organ ageing population study prostate prostate ageing prostate volume publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41965253/ ab: Background Prostate enlargement and lower urinary tract symptoms are common age-related conditions in men frequently encountered in primary care and geriatric medicine practice, yet population-level variation in prostate size and its biological drivers remain poorly defined due to limited scalable imaging. Methods We quantified prostate volume in 30 616 men using automated segmentation of whole-body MRI from the UK Biobank, establishing age-specific reference distributions across adulthood. Results Prostate volume increased continuously with age, and enlargement beyond commonly used clinical thresholds was already frequent in midlife. Multivariable analyses identified somatic (height), metabolic (body mass index and insulin-like growth factor 1), and endocrine (bioavailable testosterone) factors as independent correlates of prostate size, with stronger associations for height and bioavailable testosterone at older ages. Serum prostate-specific antigen scaled with MRI-derived prostate volume in an age-dependent manner, supporting biological validity. Larger prostates were associated with higher odds of clinically recorded lower urinary tract symptoms, with the strongest associations observed in midlife and attenuation in later life. Conclusions These findings provide population-based MRI reference values and clarify the biological and symptomatic correlates of prostate ageing, illustrating how population-scale imaging can inform the evaluation of common age-related conditions. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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