Effect of multicomponent exercise intervention on multidimensional frailty in older adults with mild cognitive impairment: a secondary analysis of the MIND-STEP randomised clinical trial.
Background Frailty is common among older adults with mild cognitive impairment (MCI) and encompasses physical, cognitive, psychological and social domains, yet randomised evidence on theory-informed multicomponent exercise interventions targeting multidimensional frailty remains limited. This second...
| Published in: | Age & Ageing Vol. 55; no. 4; pp. 1 - 14 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
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Oxford University Press / USA
Apr2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500105&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500105 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500105 10.1093/ageing/afag111 ppf: 1 ppct: 13 formats: tig: atl: Effect of multicomponent exercise intervention on multidimensional frailty in older adults with mild cognitive impairment: a secondary analysis of the MIND-STEP randomised clinical trial. aug: au: Hong, Chenlu Zhang, Na Sheng, Jiaxiu Yao, Sisi Xu, Jiali Wang, Qiuxia Li, Jun Lu, Yinke Chen, Haiqin Luo, Yanan affil: Department of Global Health, Peking University, School of Public Health, Beijing 100871, China Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou Normal University, Huzhou 313000, Zhejiang, China Department of Rehabilitation Medicine, Huzhou Rehabilitation Hospital Huzhou 313000, Zhejiang, China Department of Global Health, Peking University, School of Public Health, Beijing 100871, ChinaPeking University, Institute for Global Health and Development, Beijing 100871, ChinaPeking University, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing 100871, China su: Mental health Self-efficacy Physical fitness Social participation Behavior therapy Old age Mild cognitive impairment Secondary analysis Research funding Exercise therapy Frail elderly Questionnaires Treatment effectiveness Descriptive statistics Longitudinal method Resistance training Aerobic exercises Confidence intervals Data analysis software Disease complications sug: subj: Mental health Self-efficacy Physical fitness Social participation Behavior therapy Old age Offices of Mental Health Practitioners (except Physicians) Fitness and Recreational Sports Centers Mild cognitive impairment Secondary analysis Research funding Exercise therapy Frail elderly Questionnaires Treatment effectiveness Descriptive statistics Longitudinal method Resistance training Aerobic exercises Confidence intervals Data analysis software Disease complications keyword: copyrightHolder:British Geriatrics Society copyrightYear:2026 exercise frailty https://dx.doi.org/10.1093/ageing/afag111 inLanguage:en mild cognitive impairment minimal cognitive impairment multicomponent exercise multidimensional frailty older adult older people peer interaction peer relations publisher:Oxford University Press randomization sameAs:https://pubmed.ncbi.nlm.nih.gov/42059637/ secondary data analysis self efficacy self-efficacy enhancement copyrightHolder:British Geriatrics Society copyrightYear:2026 exercise frailty https://dx.doi.org/10.1093/ageing/afag111 inLanguage:en mild cognitive impairment minimal cognitive impairment multicomponent exercise multidimensional frailty older adult older people peer interaction peer relations publisher:Oxford University Press randomization sameAs:https://pubmed.ncbi.nlm.nih.gov/42059637/ secondary data analysis self efficacy self-efficacy enhancement ab: Background Frailty is common among older adults with mild cognitive impairment (MCI) and encompasses physical, cognitive, psychological and social domains, yet randomised evidence on theory-informed multicomponent exercise interventions targeting multidimensional frailty remains limited. This secondary analysis of the MIND-STEP RCT evaluated intervention effects across frailty domains. Methods MIND-STEP was a single-blind, parallel-group RCT conducted in nursing homes in China. Participants were randomised (1:1) to a 12-week group-based multicomponent exercise programme incorporating peer interaction and self-efficacy strategies, or to usual care. Eligible participants were adults with MCI aged ≥60 years who did not engage in regular physical exercise. Frailty domains, including physical, cognitive, psychological, social and multidimensional, were assessed at baseline, 6, 12 and 24 weeks. Generalised estimating equations within a difference-in-differences framework were used to estimate between-group risk differences. Findings Among 156 randomised participants [mean age, 69.19 years; 108 women (69.23%)], baseline prevalence was 19.23% for physical/cognitive frailty, 27.56% psychological frailty, 56.41% social frailty and 51.28% multidimensional frailty. At 12 weeks, the intervention group showed greater reductions than usual care in physical frailty (RD = −13.23%; 95% CI: −21.68% to −4.78%; P = .002), psychological frailty (RD = −13.87%; 95% CI: −25.04% to −2.69%; P = .015), cognitive frailty (RD = −18.98%; 95% CI: −28.17% to −9.79%; P < .001), and multidimensional frailty (RD = −17.79%; 95% CI: −29.21% to −6.36%; P = .002), whereas social frailty did not differ between groups. Reductions were also observed at 24-week follow-up within the study period, particularly for cognitive frailty. Interpretation In older adults with MCI, a theory-informed multicomponent exercise programme incorporating peer interaction and self-efficacy strategies was associated with improvements across multiple frailty domains at 12 weeks. Improvements were maintained at 24-week within the study period. These findings suggest a promising approach for addressing multidimensional frailty in this population, although longer-term effects require further investigation. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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