Plasma metabolites after 10-weeks of glucose vs fructose-sweetened beverages in subjects with overweight/obesity.
To identify metabolites as potential biomarkers of fructose vs glucose consumption and related metabolic changes, we conducted exploratory metabolomic profiling of fasting blood samples from participants in a double-blind, parallel-arm trial involving 31 male and female adults with overweight or obe...
| Publicado en: | Journal of the Endocrine Society Vol. 10; no. 5; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193593738&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193593738 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24721972 LBOG jtl: Journal of the Endocrine Society issn: 24721972 maglogo: N pubinfo: dt: May2026 vid: 10 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193593738 10.1210/jendso/bvag097 193593738 ppf: 1 ppct: 12 formats: tig: atl: Plasma metabolites after 10-weeks of glucose vs fructose-sweetened beverages in subjects with overweight/obesity. aug: au: Guirette, Mélanie Haslam, Danielle E Ma, Jiantao Havel, Peter J Stanhope, Kimber L Ilkayeva, Olga Newgard, Christopher B McKeown, Nicola M Herman, Mark A affil: Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA sug: ab: To identify metabolites as potential biomarkers of fructose vs glucose consumption and related metabolic changes, we conducted exploratory metabolomic profiling of fasting blood samples from participants in a double-blind, parallel-arm trial involving 31 male and female adults with overweight or obesity, both before and after supplementation with glucose- or fructose-sweetened beverages. Orthogonal Partial Least Square Discriminatory Analysis (OPLS-DA) was used to identify metabolites that could discriminate between the 2 intervention groups. Changes in 16 metabolites (5 of which are branched-chain amino acid catabolic pathway metabolites) and the branched chain keto acid (BCKA) composite score showed nominal (FDR adjusted P -value <.2, unadjusted P -value ≤.08) differences in response to the 2 interventions. We observed a 2.19 µM (or 13%) and a 10.17 µM (or 25%) increase in ketomethylvaleric acid (P FDR = 0.04, P =.001) and 2-hydroxybutyrate (P FDR = 0.11, P =.008), respectively, after glucose supplementation compared to a null change after fructose supplementation. Notable trends after fructose supplementation included increased long- and median-chain acylcarnitines (ACs); decreased short-chain ACs; and increased homocysteine compared to the glucose supplementation. These data suggest that in people with overweight/obesity, consumption of beverages high in glucose vs fructose may differentially affect the metabolism of branched-chain amino acids and acylcarnitine species reflective of changes in fatty acid oxidation and de novo lipogenesis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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