Ent-Atisane and 3,4-seco-atisane diterpenoids from Croton crocodilorum roots and their antiproliferative effect on human colorectal cancer cells.
Five previously undescribed diterpenoids (1–5) along with four known ones (6–9) were isolated from the roots of Croton crocodilorum. Most notably, the four ent -3,4- seco -atisane diterpenoids (2–5) biosynthesized from the ent -atisane diterpenoid (1) were crotogoudin derivatives. Their structures w...
| Publicado en: | Fitoterapia Vol. 191 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193806187&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193806187 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Jun2026 vid: 191 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 193806187 193806187 193806187 10.1016/j.fitote.2026.107247 193806187 ppct: 1 formats: tig: atl: Ent-Atisane and 3,4-seco-atisane diterpenoids from Croton crocodilorum roots and their antiproliferative effect on human colorectal cancer cells. aug: au: Soavina, Silvère Makhloufi, Hind Gibot-Leclerc, Léa Champavier, Yves Liagre, Bertrand Hanitriniaina, Carène Fatiany, Ruphin Razafimahefa, Solofoniaina Daugey, Nicolas Buffeteau, Thierry Millot, Marion Mambu, Lengo affil: University Limoges, LABCiS, UR 22722, Faculté de Pharmacie, F-87000 Limoges, France sug: subj: Plants, Medicinal Plant Roots Therapeutic Use Antineoplastic Agents Therapeutic Use Terpenes Metabolism Colorectal Neoplasms Drug Therapy Cell Line, Tumor Drug Effects Human Mass Spectrometry Methods Cell Proliferation Irinotecan Ketones Physiology ab: Five previously undescribed diterpenoids (1–5) along with four known ones (6–9) were isolated from the roots of Croton crocodilorum. Most notably, the four ent -3,4- seco -atisane diterpenoids (2–5) biosynthesized from the ent -atisane diterpenoid (1) were crotogoudin derivatives. Their structures were elucidated by spectroscopic data including HRESIMS and extensive 1D and 2D NMR investigations. The absolute configuration of compounds (−)-1, (−)-3 and (−)-6 was determined by vibrational circular dichroism (VCD) and Raman optical activity (ROA) spectroscopies along with density functional theory calculations. Their plausible biosynthetic pathway was proposed. All isolated diterpenoids were evaluated for their antiproliferative activity against sensitive and resistant human colorectal cancer cells (HCT116 and HT-29). Compounds 3, 5, 6 and 7 displayed more potent activities than the two positive controls (5 FU and irinotecan) against the two cancer cell lines. [Display omitted] • Five previously undescribed diterpenoids were isolated from Croton crocodilorum roots. • Their structures were established by spectroscopic methods (HRMS, NMR, VCD and ROA). • Compounds 3 , 5–7 exhibited significant antiproliferative activities against HCT 116 and HT-29 cell lines. • Structure activity relationship showed the interest of an a,b -unsaturated ketone function. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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