Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation.
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote. This review provides a comprehensive examinat...
| Publicado en: | BioMed Research International Vol. 2026; pp. 1 - 17 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
5/16/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193814966&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193814966 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 5/16/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 193814966 193814966 193814966 10.1155/bmri/5594252 193814966 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation. aug: au: Pohanka, Miroslav Gurumallesh Prabu, Poorani affil: Military Faculty of Medicine, , University of Defence, , Hradec Králové, Czech Republic, unob.cz sug: subj: Plant Proteins Poisoning Toxicology Forensic Medicine Containment of Biohazards Risk Management Biochemistry Plants, Medicinal Plants, Toxic Bioterrorism Biological Warfare Plants Emergencies Disaster Planning ab: Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote. This review provides a comprehensive examination of ricin's biochemical structure, toxicological mechanisms, and clinical manifestations, alongside its historical and potential use as a weapon. The paper explores the global distribution and utility of the castor bean plant, outlines the molecular basis of ricin's cytotoxicity, and evaluates current medical and technological countermeasures. Furthermore, it assesses international legal frameworks and policy instruments aimed at mitigating the misuse of biological agents. Case studies of ricin‐related incidents underscore the toxin's appeal to both state and nonstate actors, highlighting the need for enhanced surveillance, public awareness, and interdisciplinary preparedness. The findings emphasize the dual‐use dilemma posed by ricin and advocate for sustained international cooperation to address emerging biothreats. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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