ESBLs Antibiotic Resistance in Escherichia coli Isolated from Vaginas of Pregnant Woman Visiting Al-Zahra Hospital, Tabriz, Iran.
Background & Objective: Antibiotic resistance, particularly in bacteria producing extended-spectrum beta-lactamases (ESBLs), is a major challenge in managing bacterial infections. Here we investigated the prevalence of antibiotic resistance and its patterns in Escherichia coli strains isolated from...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 34; no. 1; pp. 31 - 40 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Jan/Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193899069&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193899069 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Jan/Feb2026 vid: 34 iid: 1 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 193899069 193899069 193899069 10.30699/jambr.34.1.31 193899069 ppf: 31 ppct: 9 formats: fmt: @attributes: type: P tig: atl: ESBLs Antibiotic Resistance in Escherichia coli Isolated from Vaginas of Pregnant Woman Visiting Al-Zahra Hospital, Tabriz, Iran. aug: au: Mansouri, Saeid Davari, Kambiz Mirani, Seyedeh Bahareh affil: Department of Biology, Sa. C., Islamic Azad University, Sanandaj, Iran. sug: subj: Escherichia Coli Infections Drug Therapy Drug Resistance, Microbial Evaluation Prescribing Patterns beta-Lactamases Expectant Mothers Hospitals Human Adult Middle Age Female Iran Funding Source Cross Sectional Studies Nonexperimental Studies Prevalence Microbiological Techniques Genes Polymerase Chain Reaction Descriptive Statistics Gram-Negative Bacteria Cefotaxime Ceftazidime Polymyxin B Gentamicins Amikacin Ciprofloxacin Trimethoprim Penicillins Drug Resistance, Multiple Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background & Objective: Antibiotic resistance, particularly in bacteria producing extended-spectrum beta-lactamases (ESBLs), is a major challenge in managing bacterial infections. Here we investigated the prevalence of antibiotic resistance and its patterns in Escherichia coli strains isolated from pregnant women attending Alzahra Hospital, Tabriz, Iran. Materials & Methods: This cross-sectional study was conducted on 100 vaginal samples collected from pregnant women. The samples were examined for identifying Escherichia coli and antibiotic resistance using microbiological tests and the E-TEST method. Additionally, the prevalence of the CTX-M, SHV, and TEM genes in ESBLproducing strains was determined using PCR. Results: Out of 100 samples, 45 (45%) were identified as Gram-negative, and 27 (27%) were confirmed to be Escherichia coli. Among the 27 E. colistrains, 9 (33.33%) were identified as ESBL producers. E-TEST results for the ESBL-producing strains revealed cefotaxime resistance ranging from 1 to 2 mg/mL and ceftazidime resistance ranging from 0.25 to 4 mg/mL. One strain showed resistance to very high concentrations (up to 256 mg/mL). The prevalence of the CTX-M and TEM genes in the ESBL-producing strains was 22.22% and 88.88%, respectively, while the SHV gene was not detected in any strain. Two strains carried both the CTX-M and TEM genes simultaneously. The overall prevalence of CTX-M and TEM genes in all isolated E. coli strains was 7.4% and 29.62%, respectively. Conclusion: These findings highlight the necessity for efficient approaches to manage antibiotic resistance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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