Circulating REG4 as an Independent Predictor of Cachexia in Gastric Cancer: Transcriptomic Evidence and Clinical Validation.
Background: Cancer cachexia (CAC) is a prevalent and debilitating complication in gastric cancer. However, specific tumor‐derived biomarkers for the screening and diagnosis of CAC remain largely unidentified. This study was designed to screen cachectic factors secreted by tumors and to investigate t...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 2026; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
5/21/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193924012&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193924012 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: 5/21/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 193924012 193924012 193924012 10.1155/jcpt/3216731 193924012 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Circulating REG4 as an Independent Predictor of Cachexia in Gastric Cancer: Transcriptomic Evidence and Clinical Validation. aug: au: Zhang, Zhige Xi, Qiulei Sui, Xiangyu Tan, Shanjun Lu, Yiding Yan, Mingyue Zhuang, Qiulin Wu, Guohao Liu, Hongda affil: Department of General Surgery Gastrointestinal Surgery/Shanghai Clinical Nutrition Research Center, , Zhongshan Hospital, , Fudan University, , Shanghai, 200032, , China, fudan.edu.cn sug: subj: Cachexia Risk Factors Stomach Neoplasms Transcriptomes Proteins Tumor Markers, Biological Predictive Value of Tests Risk Assessment Human Funding Source Female Male Middle Age Aged Comparative Studies Path Analysis Correlational Studies Descriptive Statistics Data Analysis Software T-Tests Mann-Whitney U Test Chi Square Test Fisher's Exact Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Univariate Statistics Multivariate Analysis Logistic Regression Odds Ratio Confidence Intervals ROC Curve Immunohistochemistry Enzyme-Linked Immunosorbent Assay Tomography, X-Ray Computed Tumor Necrosis Factor Sequence Analysis Gene Expression Body Composition Nutritional Status Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: Cancer cachexia (CAC) is a prevalent and debilitating complication in gastric cancer. However, specific tumor‐derived biomarkers for the screening and diagnosis of CAC remain largely unidentified. This study was designed to screen cachectic factors secreted by tumors and to investigate the value of regenerating islet‐derived family member 4 (REG4) in CAC. Methods: We enrolled 91 gastric cancer patients, stratified into a CAC group (n = 34) and a noncachectic (NC) group (n = 57). To identify cachectic factors differentially expressed by tumor tissues, bulk RNA sequencing was performed. REG4 expression was validated in tumor tissues and plasma using immunohistochemistry and enzyme‐linked immunosorbent assay, respectively. CT imaging was utilized to evaluate body composition parameters, specifically the skeletal muscle index (SMI) and subcutaneous adipose tissue index (SATI). The relationships among plasma REG4 levels, nutritional status, and body composition were analyzed. Logistic regression analysis was employed to identify risk factors for CAC, and receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of REG4. Results: RNA sequencing revealed significantly elevated REG4 gene expression in the gastric cancer tumors from the CAC group compared with the NC group. Plasma REG4 levels in the CAC group were significantly higher (p < 0.001). Correlation analysis demonstrated that elevated plasma REG4 was significantly associated with lower SMI (r = −0.24, p = 0.02), SATI (r = −0.26, p = 0.01), BMI (r = −0.26, p = 0.01), and prealbumin (r = −0.22, p = 0.04), as well as increased 6‐month weight loss (r = 0.36, p < 0.001). Multivariate logistic regression and ROC curve analysis identified high REG4 levels as an independent risk factor (OR = 7.54, 95% CI: 2.63–21.65) and a potential predictor for CAC (AUC = 0.728, 95% CI: 0.626–0.831, p < 0.001). Conclusion: In patients with gastric cancer, tumor‐derived REG4 is released into the circulation, resulting in elevated plasma levels that correlate with poor nutritional status and compromised body composition. Circulating REG4 holds promise as a novel predictor for the clinical diagnosis of CAC. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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