Implementation of second round of HPV-based screening for cervical cancer in programmatic contexts in Argentina.

Objectives. To evaluate implementation of the second round of human papillomavirus (HPV)-based cervical screening, introduced in Argentina in 2012--2014 through the Jujuy Demonstration Project for women 30 years and older, and describe the characteristics of women who adhere to the recommended five-...

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Publicado en:Pan American Journal of Public Health Vol. 49; pp. 1 - 11
Autores principales: Barbeira, Pilar Barcena, Paolino, Melisa, Binder, Fernando, Almonte, Maribel, Baena, Armando, Mazzadi, Juan David, Arrossi, Silvina
Formato: Artículo
Publicado: World Health Organization 2025
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Acceso en línea:Ver este registro en EBSCOhost
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      jtl: Pan American Journal of Public Health
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      dt: 2025
      vid: 49
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      pub: World Health Organization
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        194015666
        10.26633/RPSP.2025.92
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        atl: Implementation of second round of HPV-based screening for cervical cancer in programmatic contexts in Argentina.
      aug:
        au:
          Barbeira, Pilar Barcena
          Paolino, Melisa
          Binder, Fernando
          Almonte, Maribel
          Baena, Armando
          Mazzadi, Juan David
          Arrossi, Silvina
        affil:
          Centro de Estudios de Estado y Sociedad, Buenos Aires, Argentina
          Universidad de Buenos Aires, Buenos Aires, Argentina
          Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
          University of Toronto, Toronto, Canada
          World Health Organization, Geneva, Switzerland
          International Agency for Research on Cancer, Lyon, France
      su:
        Argentina
        Medical screening
        Medical quality control
        Health policy
        Cervical cancer diagnosis
        Cervical cancer
      sug:
        subj:
          Medical screening
          Medical quality control
          Health policy
          Argentina
          Administration of Public Health Programs
          All Other Miscellaneous Ambulatory Health Care Services
          Cervical cancer diagnosis
          Cervical cancer
      keyword:
        human papillomavirus DNA tests
        implementation science
        mass screening
        Uterine cervical neoplasms
        ciencia de la implementación
        Neoplasias del cuello uterino
        pruebas de ADN del papillomavirus humano
        tamizaje masivo
        ciência da implementação
        Neoplasias do colo do útero
        programas de rastreamento
        testes de DNA para papilomavírus humano
        human papillomavirus DNA tests
        implementation science
        mass screening
        Uterine cervical neoplasms
        ciencia de la implementación
        Neoplasias del cuello uterino
        pruebas de ADN del papillomavirus humano
        tamizaje masivo
        ciência da implementação
        Neoplasias do colo do útero
        programas de rastreamento
        testes de DNA para papilomavírus humano
      ab: Objectives. To evaluate implementation of the second round of human papillomavirus (HPV)-based cervical screening, introduced in Argentina in 2012--2014 through the Jujuy Demonstration Project for women 30 years and older, and describe the characteristics of women who adhere to the recommended five-year rescreening interval. Methods. A retrospective cohort study was conducted based on the data of two rounds of screening. All women aged 30 years or older who had been HPV-tested during the Jujuy Demonstration Project and had a negative result were included. The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework was used to evaluate implementation. Multivariable regression was used to examine factors associated with adherence to rescreening. Results. Of 42 307 HPV-negative women, 47.9% (n = 20 285) were rescreened in the second round (Reach); 69.2% of health centers provided at least one HPV test at second-round screening (Adoption); and 13.3% (n = 5 639) of women were rescreened within the recommended five-year interval. Among the total rescreened, 9.3% (n = 1 888) were HPV-positive, of which 95.0% underwent triage Pap and 79.2% of the HPV-positive/ abnormal Pap women had colposcopy. Considering women rescreened at five years, the second-round detection rate was 5.3/1 000 screened women. Rescreening at five years was significantly higher among women aged 30--44, with public health insurance, and those living in the provincial capital. Conclusions. Rescreening of HPV-negative women faced challenges linked to its reduced reach, especially if we consider the recommended five-year interval. Our findings suggest that we need to devise specific strategies to increase second-round screening rates.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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