Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder.
Although youth with attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are at increased risk for developing BD, the underlying neurobiological mechanisms remain poorly understood. Aberrant ventrolateral prefrontal cortex (VLPFC) and amygdala (AMY) functio...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 35; no. 4; pp. 1151 - 1161 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194091859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194091859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Apr2026 vid: 35 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 194091859 189382271 194091859 194091859 10.1007/s00787-025-02926-z 194091859 ppf: 1151 ppct: 10 formats: tig: atl: Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder. aug: au: Li, Qian Qin, Kun Lei, Du Li, Wenbin Tallman, Maxwell J. Patino, L. Rodrigo Sweeney, John A. Gong, Qiyong Li, Fei DelBello, Melissa P. McNamara, Robert K. affil: https://ror.org/007mrxy13 Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, No 37 Guo Xue Alley, 610041, Chengdu, Sichuan Province, P.R. China sug: subj: Attention Deficit Hyperactivity Disorder Complications Disease Susceptibility Bipolar Disorder Risk Factors Emotions Prefrontal Cortex Amygdala Functional Connectivity Family History Task Performance and Analysis Human Male Female Child Adolescence China Funding Source Exploratory Research Questionnaires DSM Analysis of Variance Chi Square Test Post Hoc Analysis Child Behavior Checklist Scales Risk Assessment Magnetic Resonance Imaging Data Analysis Software Child: 6-12 years Adolescent: 13-18 years Male Female ab: Although youth with attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are at increased risk for developing BD, the underlying neurobiological mechanisms remain poorly understood. Aberrant ventrolateral prefrontal cortex (VLPFC) and amygdala (AMY) functional connectivity (FC) have been implicated in the pathophysiology of BD. This study compared VLPFC-AMY FC in psychostimulant-free ADHD youth with (high-risk, HR) and without (low-risk, LR) a BD family history, and healthy controls (HCs). Subjects received a magnetic resonance scan while performing a continuous performance task with emotional and neutral distractors. Generalized psychophysiological interaction analysis was used to assess VLPFC-AMY FC in response to unpleasant emotional stimuli and attentional targets. A total of 144 adolescents (46 HC, 50 LR, and 48 HR) were included. In response to unpleasant emotional stimuli, FC between right VLPFC and left AMY differed among groups. HR youth exhibited lower right VLPFC-left AMY FC compared with both LR and HC, and LR youth exhibited lower right VLPFC-left AMY FC compared with HC. There were no group differences in right VLPFC-left AMY FC in response to attentional distractors. ADHD in conjunction with BD family history is associated with blunted emotion-generated right VLPFC-left AMY FC compared with ADHD youth without a BD family history and healthy youth, and may represent a neurobiological feature associated with genetic vulnerability to BD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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