Global Disparities and Trends in Radiotherapy for Early-Stage Glottic Cancer.
Simple Summary: This study evaluates current global radiotherapy practices among radiation oncologists in the management of early-stage glottic squamous cell carcinoma. The results reveal significant variations in treatment approaches across institutions and countries. These findings highlight the n...
| Publicado en: | Current Oncology Vol. 33; no. 5; pp. 259 - 273 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194129131&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194129131 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: May2026 vid: 33 iid: 5 pid: 97109 pub: MDPI artinfo: ui: 194129131 10.3390/curroncol33050259 194129131 ppf: 259 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Global Disparities and Trends in Radiotherapy for Early-Stage Glottic Cancer. aug: au: Mohamad, Issa Abu Taha, Shatha Bushehri, Ahmad Youssef, Bassem Ozyar, Enis Alotain, Ibrahim Abu-Gheida, Ibrahim Aldehaim, Mohammed Johnny, Carlton Mula-Hussain, Layth Alghamdi, Majed Shelan, Mohamed Al Dohan, Mohammed Pervez, Nadeem Elicin, Olgun Alrashidi, Saad El-Sheshtawy, Wael Temraz, Shoukri Dahbi, Zineb Abbasi, Ahmed affil: Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan sug: ab: Simple Summary: This study evaluates current global radiotherapy practices among radiation oncologists in the management of early-stage glottic squamous cell carcinoma. The results reveal significant variations in treatment approaches across institutions and countries. These findings highlight the need for international consensus and the development of standardized treatment protocols. Establishing harmonized guidelines may improve treatment quality, promote equitable patient care, reduce radiotherapy-related side effects, and potentially enhance oncologic outcomes for patients with early-stage glottic cancer worldwide. We evaluated global radiotherapy practices in the management of early-stage (AJCC/UICC 8th edition stages I-II) glottic cancer (ESGC). A cross-sectional online survey was conducted in March 2025 across centers worldwide. Data was collected on clinical practices, including staging, CT simulation, target volumes delineation, organs-at-risk contouring, radiotherapy techniques, dose and fractionation schedules, treatment delivery techniques, and image guidance practices. A total of 181 responses were received, primarily from Asia (41.4%) and Europe (24.3%). Most respondents were from non-academic public centers (44.2%), with multidisciplinary team involvement reported by 84.5%. Head and neck CT scan was the most used staging modality (80.1%). Intensity-Modulated Radiation Therapy was the most common planning technique (82.9%). Hypofractionated radiotherapy schedules predominated for T1 (84%) and T2 (72.4%) disease. T1a was typically treated with whole-larynx target volume (72.4%). Use of ipsilateral involved vocal cord irradiation varied by geographical region (p = 0.015), being most common in North America (44.8%) and Europe (38.6%). Accelerated fractionation for T2 also differed significantly (p < 0.001), with the highest use reported in North America (41.4%). Daily Cone-Beam Computed Tomography was acquired by (58.2%). In total, 70% of respondents expressed interest in the results of a future phase III randomized trial comparing stereotactic body radiation therapy to conventional radiotherapy. Significant global variations in radiotherapy practices for ESGC were observed, likely reflecting disparities in access and differences in institutional protocols. The development and implementation of standardized, evidence-based global guidelines are essential to harmonize care, minimize toxicity, and improve outcomes for patients with ESGC. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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