Decreased Serum Vitamin D Is Not Associated With Sjögren Disease in European and Asian Subjects.
Objective: To identify whether serum vitamin D [25(OH)D] and vitamin D receptor‐binding variants (VDR‐BVs) previously implicated in multiple sclerosis (MS) are associated with Sjögren disease (SjD) susceptibility and related clinical outcomes, with the overall goal of understanding the relationship...
| Publicado en: | ACR Open Rheumatology Vol. 8; no. 5; pp. 1 - 12 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194139100&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194139100 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25785745 LXGC jtl: ACR Open Rheumatology issn: 25785745 maglogo: N pubinfo: dt: May2026 vid: 8 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 194139100 194139100 194139100 10.1002/acr2.90055 194139100 ppf: 1 ppct: 11 formats: tig: atl: Decreased Serum Vitamin D Is Not Associated With Sjögren Disease in European and Asian Subjects. aug: au: Yilmaz, Defne S. Taylor, Kimberly E. Criswell, Lindsey A. Shiboski, Caroline H. Barcellos, Lisa F. affil: Division of Epidemiology, School of Public Health, University of California, Berkeley sug: subj: Sjogren's Syndrome Risk Factors Sjogren's Syndrome Risk Factors Vitamin D Deficiency Vitamin D Blood Multiple Sclerosis Risk Assessment Disease Susceptibility Outcomes (Health Care) Receptors, Cell Surface Human Europe Asia Male Female Middle Age Prospective Studies Mendelian Randomization Polymorphism, Single Nucleotide Genetic Variation Immunology Sequence Analysis Experimental Studies Genotype Quality of Care Research Descriptive Statistics Comparative Studies Logistic Regression Power Analysis Data Analysis Software Scales Goals and Objectives Middle Aged: 45-64 years Male Female ab: Objective: To identify whether serum vitamin D [25(OH)D] and vitamin D receptor‐binding variants (VDR‐BVs) previously implicated in multiple sclerosis (MS) are associated with Sjögren disease (SjD) susceptibility and related clinical outcomes, with the overall goal of understanding the relationship between vitamin D and SjD pathogenesis. Methods: We constructed genetic instrumental variables (GIVs) for 25(OH)D using results from five genome‐wide association studies and established VDR‐BVs from experimental studies and then employed a two‐sample Mendelian randomization (MR) approach. We assessed the separate associations of 25(OH)D (GIV25(OH)D) and VDR binding (GIVVDR) with SjD susceptibility and related clinical outcomes in a cohort of 984 cases and 4,595 controls of European and Asian genetic ancestry. Logistic regression was used to estimate the associations for each GIV, adjusting for the first five genome‐wide principal components and sex. Results: One VDR‐BV previously found to be causally associated with MS, rs2531804, was also significantly associated with SjD (P < 0.05) in European individuals. Decreased 25(OH)D was not significantly associated with SjD overall, or when European and Asian subgroups were considered separately. Conclusion: This study is the first to investigate genetic variants implicated in previous MR studies of the vitamin D pathway in MS for a role in SjD. Although a role for decreased serum vitamin D in SjD was not supported here, results show that variation within at least one VDR causally contributes to SjD susceptibility in European individuals. Additional research is necessary to more comprehensively understand how vitamin D contributes to SjD pathogenesis across different ancestry groups. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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