Effects of Specific Carob (Ceratonia siliqua L.) Liquid Concentrate on Glucose Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Controlled Clinical Trial.
Background/Objectives: A 90-day randomized double-blind and placebo-controlled study was conducted to assess the effect of carob (Ceratonia siliqua L.) on glucose metabolism in subjects with confirmed prediabetes. Methods: The carob liquid concentrate containing inositols of the carob fruit (D-pinit...
| Publicado en: | Nutrients Vol. 18; no. 10; pp. 1521 - 1538 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194141239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194141239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: May2026 vid: 18 iid: 10 pid: 97109 pub: MDPI artinfo: ui: 194141239 194141239 194141239 10.3390/nu18101521 194141239 ppf: 1521 ppct: 17 formats: tig: atl: Effects of Specific Carob (Ceratonia siliqua L.) Liquid Concentrate on Glucose Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Controlled Clinical Trial. aug: au: Pérez-Piñero, Silvia Muñoz-Carrillo, Juan Carlos Herrera-Fernández, Cristina Muñoz-Cámara, Macarena Hernández-Aliaga, Almudena Echepare-Taberna, Jon Ávila-Gandía, Vicente López-Román, Francisco Javier affil: Health Sciences Department, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Carretera de Guadalupe s/n, Guadalupe, E-30107 Murcia, Spain sug: subj: Plant Extracts Pharmacodynamics Blood Glucose Metabolism Prediabetic State Drug Therapy Treatment Outcomes Human Randomized Controlled Trials Double-Blind Studies Male Female Adolescence Adult Middle Age Aged Random Assignment Plant Extracts Administration and Dosage Placebos Administration and Dosage Glucose Tolerance Test ROC Curve Evaluation Insulin Blood Glycated Hemoglobin Analysis Immunoassay Diet Records Repeated Measures Analysis of Variance Post Hoc Analysis Mann-Whitney U Test Friedman Test Data Analysis Software Funding Source Lipoproteins, LDL Cholesterol Analysis Triglycerides Analysis Blood Glucose Analysis Insulin Resistance Evaluation Insulin Sensitivity Drug Therapy Medication Compliance Evaluation Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background/Objectives: A 90-day randomized double-blind and placebo-controlled study was conducted to assess the effect of carob (Ceratonia siliqua L.) on glucose metabolism in subjects with confirmed prediabetes. Methods: The carob liquid concentrate containing inositols of the carob fruit (D-pinitol, myo-inositol, D-chiro inositol) was administered at a daily dose of 6.66 g, divided into two doses of 3.33 g each. Study variables included glucose- and insulin-related parameters obtained at fasting conditions and during a standard 2 h oral glucose tolerance test (OGTT) at baseline and after 45 and 90 days of administration of the study products. Results: The study population included 52 subjects (25 in the experimental group, 27 in the placebo group), 27 men and 25 women, with a mean age of 45.6 ± 13.9 years. Subjects who consumed the active product showed improvements in glycated hemoglobin (HbA1c) and glucose levels as compared with placebo (p < 0.001 of the time × group interaction). Fasting serum insulin showed within-group significant decreases in the experimental group, with insulin indexes (HOMA-IR and QUICKI) improving significantly in the experimental group only. In the OGTT, there were significant improvements in the AUC of glucose and insulin, as well as glucose peak in the experimental group only. The product was well tolerated and no adverse effects were recorded. Conclusions: The use of a specific carob-based liquid concentrate decreased HbA1c and glucose levels in subjects with prediabetes, which may suggest its potential clinical relevance in the prevention of the transition from prediabetes to overt type 2 diabetes. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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