Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD.

Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in aut...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 56; no. 6; pp. 2391 - 2408
Autores principales: Forbes, Elana J., Tiego, Jeggan, Langmead, Joshua, Unruh, Kathryn E., Mosconi, Matthew W., Finlay, Amy, Kallady, Kathryn, Maclachlan, Lydia, Moses, Mia, Cappel, Kai, Knott, Rachael, Chau, Tracey, Sindhu, Vishnu Priya Mohanakumar, Bellato, Alessio, Groom, Madeleine J., Kerestes, Rebecca, Bellgrove, Mark A., Johnson, Beth P.
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jun2026
Acceso en línea:Ver este registro en EBSCOhost
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          Forbes, Elana J.
          Tiego, Jeggan
          Langmead, Joshua
          Unruh, Kathryn E.
          Mosconi, Matthew W.
          Finlay, Amy
          Kallady, Kathryn
          Maclachlan, Lydia
          Moses, Mia
          Cappel, Kai
          Knott, Rachael
          Chau, Tracey
          Sindhu, Vishnu Priya Mohanakumar
          Bellato, Alessio
          Groom, Madeleine J.
          Kerestes, Rebecca
          Bellgrove, Mark A.
          Johnson, Beth P.
        affil: https://ror.org/02bfwt286 School of Psychological Sciences, Monash University, 18 Innovation Walk, 3800, Melbourne, VIC, Australia
      sug:
        subj:
          Autism Spectrum Disorder Australia
          Attention Deficit Hyperactivity Disorder
          Comorbidity
          Eye Movements Physiology
          Eye Movements Physiology
          Saccades
          Human
          Australia
          Child
          Adolescence
          Scales
          Task Performance and Analysis
          Descriptive Statistics
          Multiple Regression
          Post Hoc Analysis
          Child: 6-12 years
          Adolescent: 13-18 years
      ab: Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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