Pharmacologic Modulation of Circadian Rhythms for Delirium Prevention: An Age‐Stratified Systematic Review and Meta‐Analysis.

Background: Disturbances in sleep–wake homeostasis (Process S) and circadian rhythm (Process C) are common precipitants of delirium, especially among older hospitalized adults. We conducted a systematic review and meta‐analysis to test whether four sleep‐modulation agents—melatonin, ramelteon, suvor...

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Bibliographic Details
Published in:	Journal of the American Geriatrics Society Vol. 74; no. 5; pp. 1439 - 1450
Main Authors:	de Oliveira, Helen Michaela, Gallo Ruelas, Mariano, Parker, Tariq, Diaz, Camilo André Viana, Oliveira de Paula, Guilherme, Zamora, Fernanda Valeriano, Fruett da Costa, Pablo Ramon
Format:	Article
Published:	Wiley-Blackwell May2026
Subjects:	Age distribution Old age Medical information storage & retrieval systems Sedatives Melatonin Hospital patients Meta-analysis Relative medical risk Descriptive statistics Systematic reviews MEDLINE Delirium Circadian rhythms Online information services Confidence intervals Data analysis software Regression analysis Publication bias
Online Access:	View this record in EBSCOhost

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