A Randomized Trial to Evaluate the Efficacy of a Pain Neuroscience Education Program on Executive Function and Pain Intensity in Women With Fibromyalgia.

To evaluate the efficacy of a brief, structured pain neuroscience education (PNE) program on executive function and pain intensity in women with fibromyalgia (FM). Randomized clinical trial. Rheumatology and pain clinics in Mexico and Colombia. Sixty-two women aged 40-60 years diagnosed with FM acco...

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Publicado en:Archives of Physical Medicine & Rehabilitation Vol. 107; no. 6; pp. 1258 - 1268
Autores principales: Morales-Osorio, Marco Antonio, Ordoñez-Mora, Leidy Tatiana, Mejía-Mejía, Johana, Román, Fabian, Lopez-Perez, Pedro Javier, Ramírez-Vélez, Robinson
Formato: research randomized controlled trial Journal Article
Publicado: W B Saunders Jun2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2026
      vid: 107
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      pub: W B Saunders
      place: Philadelphia, Pennsylvania
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        10.1016/j.apmr.2026.02.006
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        atl: A Randomized Trial to Evaluate the Efficacy of a Pain Neuroscience Education Program on Executive Function and Pain Intensity in Women With Fibromyalgia.
      aug:
        au:
          Morales-Osorio, Marco Antonio
          Ordoñez-Mora, Leidy Tatiana
          Mejía-Mejía, Johana
          Román, Fabian
          Lopez-Perez, Pedro Javier
          Ramírez-Vélez, Robinson
        affil: Universidad San Sebastián, Facultad de Ciencias de la Rehabilitación y Calidad de Vida, Escuela de Kinesiología, Carrera de Kinesiología, Concepción, Chile
      sug:
        subj:
          Fibromyalgia
          Women's Health
          Neuroscience Care Education
          Program Evaluation
          Executive Function Evaluation
          Pain Measurement
          Human
          Mexico
          Colombia
          Female
          Adult
          Middle Age
          Randomized Controlled Trials
          Random Assignment
          Task Performance and Analysis
          Visual Analog Scaling
          Questionnaires
          Wisconsin Card Sorting Test
          Descriptive Statistics
          Anxiety Evaluation
          Comparative Studies
          Depression
          Memory, Short Term
          State-Trait Anxiety Inventory
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
      ab: To evaluate the efficacy of a brief, structured pain neuroscience education (PNE) program on executive function and pain intensity in women with fibromyalgia (FM). Randomized clinical trial. Rheumatology and pain clinics in Mexico and Colombia. Sixty-two women aged 40-60 years diagnosed with FM according to American College of Rheumatology 2010 criteria. Participants were randomly divided to either PNE plus usual care or usual care alone. The intervention consisted of ten 40-45-minute online PNE sessions delivered over 5 weeks. Coprimary outcomes were pain intensity, assessed with the visual analog scale; FM impact, assessed with the Fibromyalgia Impact Questionnaire–Revised; and executive function (multidimensional domain), assessed with 4 tasks: the Wisconsin Card Sorting Test (cognitive flexibility), the Simon Task (inhibition), the Corsi Block-Tapping Task (visuospatial working-memory capacity), and the Digit Span Forward Task (phonological working-memory capacity). Secondary outcomes were central sensitization (Central Sensitization Inventory), pain catastrophizing (Pain Catastrophizing Scale), kinesiophobia (Tampa Scale for Kinesiophobia-11), depressive symptoms (Beck Depression Inventory-II), and anxiety (State-Trait Anxiety Inventory). Compared with controls, the PNE group showed greater reductions in pain (−3.24; P =.001), FM impact (−15.14; P =.001), central sensitization (−22.36; P =.001), catastrophizing (−7.24; P =.020), and kinesiophobia (−8.68; P =.001). Depressive symptoms also improved (−6.78; P =.023). Trait anxiety decreased more in the control group (P =.001). Executive-function effects were domain specific: phonological working memory (Digit Span Forward) improved significantly (P =.007), whereas no significant effects were observed for visuospatial working memory, cognitive flexibility, or inhibition after multiplicity adjustment. PNE plus usual care significantly improves pain, functional impact, central sensitization, catastrophizing, kinesiophobia, and phonological working memory in FM. Cognitive effects were selective (no improvement in flexibility, inhibition, or visuospatial working memory) and mood outcomes were mixed.
      pubtype: Academic Journal
      doctype:
        research
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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