| Sumario: | Significance & Background: Oncology nurses play a critical role in the early identification and management of hypersensitivity reactions (HSRs). However, limited exposure and training can hinder nurses' confidence and clinical readiness. Purpose: The primary aim of this project is the enhance oncology nurses' confidence and competence in recognizing and managing HSRs through a structured, three-step educational and clinical immersion program. Interventions: Participating nurses completed a sequential three-step intervention: E-learning Module: online training on HSRs, followed by a post test to assess knowledge acquisition; Live Educational Session: a case-based learning session incorporating simulation of HSR scenarios; and Clinical Immersion: a one-shift precepted rotation within the Ambulatory Desensitization Program to gain hands-on experience. Nurse confidence is measured using a self-reported survey administered at two time points: prior to Step 2, and one-month post-completion. Clinical competency was validated prior to the second survey to ensure proficiency. Results: Data will be collected from September 2025 through January 2026. Eleven eligible registered nurses (RNs) from the Ambulatory Infusion Unit have been enrolled, with participation prioritized from least to most senior staff. Five RNs with demonstrated HSR proficiency currently serve as program leads. Program success will be evaluated using the following metrics: RN HSR competency, non-hospitalized HSR rates, HSR-related ED/hospital visits, and confidence in HSR management post-intervention. Discussion: This initiative addresses a critical gap in oncology nursing: equipping staff to identify and manage hypersensitivity reactions (HSRs). Using a structured, multimodal approach--didactic learning, case study, and clinical immersion. Competency validation and confidence assessments will measure impact. The program expected outcomes are: enhanced nurse preparedness, reduced HSR-related complications, improved patient safety, and a culture of continuous learning through RN mentorship. Challenges to implementation may include staffing to support clinical rotations, variability in nurses' baseline experience, and the need for continuous program evaluation to ensure relevance and effectiveness. Nevertheless, the phased rollout and incorporation of measurable outcomes establish a solid framework for scalable growth and long-term integration into oncology nursing education. If successful, the model can be adapted to other high-risk scenarios, showcasing the value of experiential learning in clinical care.
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