| Sumario: | Science Background & Significance: Evidence-Based Practice (EBP) is internationally recognized as a key component of high-quality healthcare and improved patient outcomes, including the advancement of nursing practice. However, implementing EBP among nurses in tertiary hospitals in Saudi Arabia remains a significant challenge. Purpose: To explore the barriers affecting the implementation of EBP among nurses working in tertiary hospitals across Saudi Arabia. Methods: A multicenter, cross-sectional correlational design was used. Data were collected from several hospitals located in different regions of the country. A random sampling method was employed to ensure representation of diverse nursing experiences. The final sample size was determined based on the total number of nurses in the selected hospitals. Findings and Interpretations: Nurses from both oncology and general hospital units participated in the study. Overall, moderate to high barriers to EBP implementation were reported. The most frequently cited challenges included lack of time to read research, limited access to resources, and insufficient authority to change clinical protocols. Oncology nurses reported higher average barrier scores (mean = 4.1) compared to general nurses (mean = 3.8), a statistically significant difference (p = 0.03). This elevated score may reflect the high acuity and demanding workload in oncology settings, which limits time and energy for research engagement. Discussion: Identifying barriers to EBP implementation can support healthcare leaders in developing targeted strategies, including EBP education, mentorship programs, and clear practice guidelines. These efforts aim to improve the quality of care delivered by nurses at all levels within tertiary hospitals. Moreover, these findings highlight the need for tailored strategies that address the unique pressures faced by oncology nurses to ensure equitable access to EBP resources and opportunities.
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