Clinical Immunology for Heart Transplant Nurses: Medication Decision-Making.
Heart transplantation offers life-saving therapy for patients with end-stage heart disease, but outcomes depend on precise management of immune risk and immunosuppression. The transplanted heart is a potent antigenic stimulus that can trigger immune pathways, leading to rejection and graft dysfuncti...
| Publicado en: | AACN Advanced Critical Care Vol. 37; no. 2; pp. 185 - 204 |
|---|---|
| Autores principales: | , , |
| Formato: | CEU review Journal Article |
| Publicado: |
American Association of Critical-Care Nurses
Summer2026
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194229621&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194229621 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15597768 26ZY jtl: AACN Advanced Critical Care issn: 15597768 maglogo: N pubinfo: dt: Summer2026 vid: 37 iid: 2 pid: 2559 pub: American Association of Critical-Care Nurses place: Alisa Veijo, California artinfo: ui: 194229621 194229621 194229621 10.4037/aacnacc2026133 194229621 ppf: 185 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Clinical Immunology for Heart Transplant Nurses: Medication Decision-Making. aug: au: Coleman, Bernice Guzman, Ariz Amoroso Vo, Ashley A. affil: Bernice Coleman is Director, Nursing Research and Quality Improvement; Research Scientist III Nurse Practitioner, Heart Transplantation and Mechanical Circulatory Support Programs; Assistant Professor, Biomedical Sciences and Medicine, Cedars-Sinai Medical Center, 6500 Wilshire Blvd, Suite 1220, Los Angeles, CA 90048 sug: subj: Heart Transplantation Nursing Transplantation Immunology Transplant Nurses Medication Management Decision Making, Clinical Transplant Recipients Education, Continuing (Credit) Heart Diseases Surgery Heart Diseases Prognosis Risk Assessment Immunosuppression Graft Rejection Critical Care Nurses Advanced Practice Registered Nurses Nursing Knowledge Early Diagnosis Patient Education Patient Bedside Phenotype T Lymphocytes Physiology Histocompatibility Antibody Formation Immunosuppressive Agents Therapeutic Use Drug Monitoring Patient Safety Postoperative Care Gene Expression Profiling Signal Transduction Immune System Physiology HLA Antigens Induction Chemotherapy Esterases Antagonists and Inhibitors Enzyme Inhibitors Therapeutic Use Cell Proliferation Drug Effects Adrenal Cortex Hormones Therapeutic Use MTOR Inhibitors Therapeutic Use Belatacept Therapeutic Use Abatacept Therapeutic Use Cell-Free Nucleic Acids ab: Heart transplantation offers life-saving therapy for patients with end-stage heart disease, but outcomes depend on precise management of immune risk and immunosuppression. The transplanted heart is a potent antigenic stimulus that can trigger immune pathways, leading to rejection and graft dysfunction if not adequately controlled. Intensive care unit nurses and advanced practice registered nurses need a working knowledge of transplant immunology because daily decisions about rejection surveillance, immunosuppressive medication management, early recognition of rejection risk, and patient education are grounded in these mechanisms. Recipient alloactivation occurs through direct and indirect pathways that shape the timing and phenotype of rejection. Acute cellular rejection is primarily T-cell mediated through major histocompatibility complex interactions, while antibody-mediated rejection is driven by donor-specific antibodies against human leukocyte antigens with complement activation and endothelial injury. This review links core immunology to bedside medication monitoring and safer, consistent post-transplant care. pubtype: Academic Journal doctype: CEU review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|