AI-Guided Coronary Plaque Analysis from Coronary CTA: An Emerging Paradigm for Personalized Preventive Cardiology.

Coronary artery disease (CAD) remains the leading cause of death worldwide and is driven by atherosclerotic plaque formation. Due to advances in CT technology, coronary CTA (CCTA) has emerged as a leading noninvasive imaging technique to analyze the coronary artery lumen and atherosclerotic plaque....

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Publicado en:Applied Radiology Vol. 55; no. 3; pp. 1 - 10
Autores principales: Basunia, Azfar, Jagasia, Dinesh, Jamal, Faisal
Formato: diagnostic images pictorial review tables/charts Journal Article
Publicado: Anderson Publishing Ltd. May2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: May2026
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      pub: Anderson Publishing Ltd.
      place: Scotch Plains, New Jersey
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        atl: AI-Guided Coronary Plaque Analysis from Coronary CTA: An Emerging Paradigm for Personalized Preventive Cardiology.
      aug:
        au:
          Basunia, Azfar
          Jagasia, Dinesh
          Jamal, Faisal
        affil: Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania
      sug:
        subj:
          Artificial Intelligence Utilization
          Algorithms Utilization
          Image Processing, Computer Assisted Methods
          Computed Tomography Angiography Methods
          Atherosclerosis Radiography
          Coronary Arteriosclerosis Radiography
          Cardiovascular Diseases Prevention and Control
          Coronary Stenosis Diagnosis
          Risk Assessment
          Cardiovascular Risk Factors
          Individualized Medicine
          Atherosclerosis Physiopathology
      ab: Coronary artery disease (CAD) remains the leading cause of death worldwide and is driven by atherosclerotic plaque formation. Due to advances in CT technology, coronary CTA (CCTA) has emerged as a leading noninvasive imaging technique to analyze the coronary artery lumen and atherosclerotic plaque. CCTA can characterize plaque types (calcified, noncalcified, and lowattenuation [lipid-rich]) components, which carry different risks. Total plaque burden measured on CCTA, especially the volume of noncalcified plaque, has emerged as a strong predictor of acute coronary syndrome (ACS), independent of traditional risk factors and calcium score. Contemporary CCTA reporting requires manual plaque segmentation, which can be time-intensive and show suboptimal inter- and intraobserver reproducibility. Artificial intelligence-guided quantitative plaque analysis (AI-QPA) algorithms have emerged to address these challenges and increase analytic throughput. In multiple studies over the past few years, AI-QPA has demonstrated superiority over conventional myocardial perfusion imaging and achieved excellent agreement with expert human readers and invasive imaging. Furthermore, the therapeutic basis of lipid-lowering medications was demonstrated using AI-QPA, ushering in an era of personalized preventative cardiology. This review briefly delves into the common AI-QPA workflow, the inner workings, and validation for the 3 most common commercially available AI-QPA platforms: Cleerly, HeartFlow, and PlaqueIQ (Elucid).
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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