Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate.
Probiotic supplementation is gaining attention for its role in maintaining health and enhancing the quality of life of the elderly. Leukocyte telomere length (LTL) is a biomarker of cellular aging, with shorter LTL associated with cardiovascular morbidity and mortality. This study explored whether p...
| Publicado en: | Journal of Medicinal Food Vol. 29; no. 7; pp. 438 - 444 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194356978&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194356978 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1096620X C1S jtl: Journal of Medicinal Food issn: 1096620X maglogo: N pubinfo: dt: Jul2026 vid: 29 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 194356978 194356978 194356978 10.1177/1096620X251400155 194356978 ppf: 438 ppct: 6 formats: tig: atl: Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate. aug: au: Coman, Maria Magdalena Torbidoni-Baldassari, Benedetta Occhigrossi, Lucia Deiana, Giovanni Silvi, Stefania Verdenelli, Maria Cristina Napolioni, Valerio affil: SYNBIOTEC Srl, Camerino, Italy. sug: subj: Probiotics Therapeutic Use Dietary Supplementation In Old Age Leukocytes Metabolism Telomere Metabolism Lactobacillus Inflammation Prevention and Control Ethnic Groups Italians In Old Age Outcomes (Health Care) Human Funding Source Male Female Middle Age Aged Aged, 80 and Over Randomized Controlled Trials Random Assignment Double-Blind Studies Mann-Whitney U Test Descriptive Statistics Data Analysis Software Reverse Transcriptase Polymerase Chain Reaction Prospective Studies Leukocytes Physiology Telomere Physiology Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Probiotic supplementation is gaining attention for its role in maintaining health and enhancing the quality of life of the elderly. Leukocyte telomere length (LTL) is a biomarker of cellular aging, with shorter LTL associated with cardiovascular morbidity and mortality. This study explored whether probiotics could counteract LTL attrition in an ethnically homogeneous cohort of older adults over a 6-month period. Samples were selected from the PROBIOSENIOR trial, a randomized, double-blind, placebo-controlled study involving 46 participants (≥60 years). Participants were randomized to receive either SYNBIO® probiotics (5 × 109 CFU/daily dose) or a placebo for 6 months. Genomic DNA was extracted from blood samples at baseline, and 6 months later, LTL measures were obtained via quantitative PCR. A general linear model assessed the "treatment x time" interaction as the main outcome. LTL was successfully assessed for all participants (N = 46 × 2 time points). Statistical analysis revealed a significant "treatment x time" interaction (P =.034), indicating a reduced LTL attrition rate in the probiotic group compared with the placebo group. A 6-month supplementation with SYNBIO probiotics significantly reduced LTL attrition in an ethnically homogeneous cohort of elderly adults. These findings suggest that probiotics may serve as a simple and effective intervention to mitigate cellular aging and promote healthy aging. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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