Performance of Magnetic Resonance Imaging-based Permeability Indices for Preoperative Glioma Grading.
Introduction: Due to the inherent limitations of histopathology as the gold standard method for glioma grading, in recent years, alternative methods, including methods based on imaging data, have been proposed for better glioma grading. This study aimed to determine the performance of permeability p...
| Published in: | Journal of Basic Research in Medical Sciences Vol. 13; no. 1; pp. 34 - 43 |
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| Main Authors: | , |
| Format: | diagnostic images equations & formulas research tables/charts Journal Article |
| Published: |
Ilam University of Medical Sciences
2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194361504&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194361504 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23830506 N1MR jtl: Journal of Basic Research in Medical Sciences issn: 23830506 maglogo: N pubinfo: dt: 2026 vid: 13 iid: 1 pid: 63388 pub: Ilam University of Medical Sciences artinfo: ui: 194361504 194361504 194361504 194361504 ppf: 34 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Performance of Magnetic Resonance Imaging-based Permeability Indices for Preoperative Glioma Grading. aug: au: Alikhani, Sina Zakariaee, Seyed Salman affil: Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran sug: subj: Glioma Classification Neoplasm Staging Preoperative Period Magnetic Resonance Imaging Methods Sensitivity and Specificity Permeability Human Funding Source Male Female Adult Middle Age Retrospective Design Record Review Cross Sectional Studies Descriptive Statistics Data Analysis Software Mann-Whitney U Test ROC Curve Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Introduction: Due to the inherent limitations of histopathology as the gold standard method for glioma grading, in recent years, alternative methods, including methods based on imaging data, have been proposed for better glioma grading. This study aimed to determine the performance of permeability parameters (Ktrans, Kep, Ve, and Vp) quantified using the dynamic contrast-enhanced MRI (DCE-MRI) method for preoperative glioma grading. Materials & Mediods: The radiological data of 31 patients with pathologically confirmed gliomas were retrospectively reviewed. The permeability parameters, including Ktrans, Kep, Ve, and Vp, were quantified using DCE-MRI data. The Mann-Whitney U test was used to assess the significance of differences in these parameters between different grades of glioma. The performance of the parameters for glioma grading was evaluated using receiver operating characteristic (ROC) curve analysis. Results: The mean age of the patients was 39.2 ± 14.1 years, and 18 of the participants were males (58.06%). Ktrans, Kep, and Vp parameters demonstrated a significant difference between different grades of glioma. The results showed that Ktrans yielded the best grading performance compared to other studied parameters (AUC>71%). Vp, Kep, and Ve parameters ranked next. Conclusion: DCE-MRI provides valuable quantitative parameters that can reliably differentiate between glioma grades. These noninvasive imaging biomarkers can serve as a powerful complement to the standard histopathological grading system, guiding better treatment planning and preventing unnecessary interventions. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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