Revolutionizing Stem Cell Sorting with Machine Learning: A Review of Trends, Tools, and Future Directions.

Stem cells are critical tools in regenerative medicine, large-scale cell production, drug discovery, and cell-based therapies, making their precise identification and sorting essential for advancing both research and clinical applications. Accurate stem cell sorting enables improved therapeutic outc...

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Publicado en:Iranian Journal of Medical Sciences Vol. 51; no. 5; pp. 285 - 305
Autores principales: Mousazadeh, Marziyeh, Jahangiri-Manesh, Atieh, Soltaninejad, Hossein, Yazdi, Farzaneh, Rahimian, Karim, Curran, Kathleen M., Khashayar, Patricia
Formato: pictorial review tables/charts Journal Article
Publicado: Shiraz University of Medical Sciences May2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: May2026
      vid: 51
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      pub: Shiraz University of Medical Sciences
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        10.30476/ijms.2025.107395.4197
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        atl: Revolutionizing Stem Cell Sorting with Machine Learning: A Review of Trends, Tools, and Future Directions.
      aug:
        au:
          Mousazadeh, Marziyeh
          Jahangiri-Manesh, Atieh
          Soltaninejad, Hossein
          Yazdi, Farzaneh
          Rahimian, Karim
          Curran, Kathleen M.
          Khashayar, Patricia
        affil: Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
      sug:
        subj:
          Stem Cells Analysis
          Machine Learning Utilization
          Cell Separation Methods
          Cell Separation Trends
          Cell Separation Equipment and Supplies
          Data Management
          Stem Cells Classification
          Cell Biology
          Artificial Intelligence
          Flow Cytometry
          Technology, Medical History
          Machine Learning History
          Autoanalyzers
          Cytological Techniques, Automated
          Software
          Automation, Laboratory
          Deep Learning
          Research, Medical
          Bioinformatics
          Photography
          Videorecording
          Microarray Analysis
          Biomechanics
          Machine Learning Algorithms
          Electrophysiology
          Gene Expression
          Image Processing, Computer Assisted
      ab: Stem cells are critical tools in regenerative medicine, large-scale cell production, drug discovery, and cell-based therapies, making their precise identification and sorting essential for advancing both research and clinical applications. Accurate stem cell sorting enables improved therapeutic outcomes, efficient production pipelines, and more reliable biological studies. Traditional sorting methods, while effective, face challenges related to speed, scalability, cost, and human error. Recent advances in machine learning (ML) techniques based on image and video processing have revolutionized stem cell sorting by enabling rapid, automated, and highly accurate classification. In addition to visual data approaches, non-visual processing methods using ML have also emerged as powerful tools for stem cell analysis and separation. In this review, various ML-driven strategies for stem cell sorting, with a particular focus on visual and non-visual data processing methodologies and their applications in different stem cell types, have been comprehensively explored and categorized based on the input data types, ML techniques, stem cell types, study objectives, and performance metrics. Furthermore, an overview of the historical development of stem cell sorting technologies and ML applications was introduced, and emerging automated systems, software solutions, start-ups, and future directions for this type of stem cell sorters were discussed.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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