Direct Immunofluorescence Positivity Rates as a Potential Identification Marker Between Oral Lichen Planus and Oral Lichenoid Lesion: A Systematic Review and Meta‐Analysis.
Background: The present study intends to evaluate the potential role of direct immunofluorescence (DIF) in the differential diagnosis of oral lichen planus (OLP) and oral lichenoid lesion (OLL) by means of meta‐analysis. Methods: An exhaustive literature search across international databases (PubMed...
| Publicado en: | Oral Diseases Vol. 32; no. 4; pp. 953 - 966 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194418680&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194418680 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1354523X DZP jtl: Oral Diseases issn: 1354523X maglogo: Y pubinfo: dt: Apr2026 vid: 32 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 194418680 191571815 194418680 194418680 10.1111/odi.70208 194418680 ppf: 953 ppct: 13 formats: tig: atl: Direct Immunofluorescence Positivity Rates as a Potential Identification Marker Between Oral Lichen Planus and Oral Lichenoid Lesion: A Systematic Review and Meta‐Analysis. aug: au: Li, Renzhi Hao, Ziyan Zhang, Shuqi Liu, Jinying Wang, Hui affil: Department of Oral Medicine, Capital Medical University, School of Stomatology, Beijing, China sug: subj: Lichen Planus, Oral Diagnosis Lichenoid Eruptions Diagnosis Fluorescent Antibody Technique Diagnosis, Differential Biological Markers Human Funding Source Female Male Adult Middle Age Aged Systematic Review Meta Analysis Descriptive Statistics PubMed Embase Cochrane Library Data Analysis Software Tissue Fibrin Immunoglobulins Checklists kappa Statistic Confidence Intervals Odds Ratio Sensitivity and Specificity Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: The present study intends to evaluate the potential role of direct immunofluorescence (DIF) in the differential diagnosis of oral lichen planus (OLP) and oral lichenoid lesion (OLL) by means of meta‐analysis. Methods: An exhaustive literature search across international databases (PubMed, Scopus, Embase, Cochrane Library and Web of Science) was performed up to October 2025. Quality evaluation was conducted on the retrieved studies, literature management was performed using EndNote 21.3 (Clarivate Analytics, Philadelphia, PA, USA) and meta‐analyses were executed using RevMan 5.4 (The Cochrane Collaboration, London, UK) and Stata 18.0 (StataCorp LLC, College Station, TX, USA). Results: Five studies were included in total, encompassing 465 participants. This meta‐analysis of DIF positivity rates in tissues demonstrated significant differences with the following three antibodies between OLP and OLL: fibrin (Fib), IgA, IgM. The area under the curve (AUC) values of Fib and IgA indicated moderate diagnostic efficacy. Conclusions: Pooled analysis of five studies revealed that Fib, IgA, and IgM exhibited significantly higher positive rates in OLP than in OLL, indicating their promising potential for aiding the differential diagnosis of OLP. However, sole reliance on the positivity of a single antibody is insufficient for distinguishing OLP from OLL. Further research on the immunofluorescence patterns of these antibodies will help clarify the diagnostic criteria. Trial Registration: This report was preregistered on PROSPERO with the registration ID CRD420251088424; the registration form is provided in Appendix 1 pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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