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Comment on: "Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide"...Li H-Y, Cheriyan J, Chan T-K, et al. American Journal of Cardiovascular Drugs. 2026;26(1):107-120.

This article focuses on a trial sequential analysis (TSA) conducted to evaluate the robustness of colchicine’s effect on major adverse cardiovascular events (MACE) in cardiovascular disease (CVD) populations, based on a prior meta-analysis of 14 randomized controlled trials. The TSA found that while...

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Published in:American Journal of Cardiovascular Drugs Vol. 26; no. 4; pp. 507 - 510
Main Authors: Konipineni, Sunil, Valecha, Jayesh, Meme, Caroline Ducatti, Rodrigues, Amanda Cyntia Lima Fonseca
Format: commentary letter tables/charts Journal Article
Published: Springer Nature Jul2026
Online Access:View this record in EBSCOhost
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      dt: Jul2026
      vid: 26
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      pub: Springer Nature
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        10.1007/s40256-026-00801-z
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        atl: Comment on: "Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide"...Li H-Y, Cheriyan J, Chan T-K, et al. American Journal of Cardiovascular Drugs. 2026;26(1):107-120.
      aug:
        au:
          Konipineni, Sunil
          Valecha, Jayesh
          Meme, Caroline Ducatti
          Rodrigues, Amanda Cyntia Lima Fonseca
        affil: https://ror.org/01pc8e529 Department of Internal Medicine, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine
      sug:
        subj:
          Cardiovascular Diseases Prevention and Control
          Colchicine Therapeutic Use
          Major Adverse Cardiac Events Prevention and Control
          Colchicine Adverse Effects
          Odds Ratio
          Confidence Intervals
          Decision Making, Clinical
      ab: This article focuses on a trial sequential analysis (TSA) conducted to evaluate the robustness of colchicine’s effect on major adverse cardiovascular events (MACE) in cardiovascular disease (CVD) populations, based on a prior meta-analysis of 14 randomized controlled trials. The TSA found that while colchicine’s benefit in the overall CVD population is statistically robust, the evidence for its effect in the acute atherothrombotic CVD subgroup remains inconclusive due to insufficient information size and potential type I error. These results highlight the need for cautious interpretation of subgroup findings in cumulative meta-analyses and suggest that clinical decisions should prioritize evidence from the broader CVD population until further adequately powered trials clarify colchicine’s efficacy in specific subgroups.
      pubtype: Academic Journal
      doctype:
        commentary
        letter
        tables/charts
        Journal Article
      ougenre: Unknown
    language: English
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